Research Article

Extracts of Cistanche deserticola Can Antagonize Immunosenescence and Extend Life Span in Senescence-Accelerated Mouse Prone 8 (SAM-P8) Mice

Figure 1

The effects of extracts of Cistanche deserticola (ECD) on life span of SAM-P8 mice. Eight-month-old male senescence-accelerated mouse/prone 8 (SAM-P8) mice were randomly divided into 4 groups (in each group, ): 3 treatment groups, and a no treatment control group. The nonsenescent substrain (SAM-R1) of mice was used as an experimental control. The food intake of all of animals was monitored throughout the experiment at 3-day intervals. The 3 treatment groups were fed ad libitum on diets supplemented with low (50 mg/kg), medium (150 mg/kg), and high (450 mg/kg) doses of Cistanche deserticola extract (ECD). The two control animal groups were fed with the same diet without ECD supplementation. (a) Kaplan-Meier survival curves of SAM-P8 mice dieted ECD or vehicle control. The Kaplan-Meier survival analysis was conducted using the Log-rank (Mantel-Cox) and Gehan-Breslow-Wilcoxon tests. (b) Histogram of the average life span of the groups of mice. The error bars show that the standard deviation from the mean and statistical significance was carried out using ANOVA analysis followed by post hoc -test. SAM-P8 versus SAM-R1; high dose treated group versus SAM-P8; medium dose treated group versus SAM-P8 (in each group, ).
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