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Evidence-Based Complementary and Alternative Medicine
Volume 2014 (2014), Article ID 642942, 12 pages
Cinnamon: A Multifaceted Medicinal Plant
1Faculty of Agro Based Industry, Universiti Malaysia Kelantan, Jeli Campus, Locked Bag No. 100, 17600 Jeli, Kelantan, Malaysia
2Human Genome Centre, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
Received 1 January 2014; Accepted 12 March 2014; Published 10 April 2014
Academic Editor: Mohammad Amjad Kamal
Copyright © 2014 Pasupuleti Visweswara Rao and Siew Hua Gan. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Cinnamon (Cinnamomum zeylanicum, and Cinnamon cassia), the eternal tree of tropical medicine, belongs to the Lauraceae family. Cinnamon is one of the most important spices used daily by people all over the world. Cinnamon primarily contains vital oils and other derivatives, such as cinnamaldehyde, cinnamic acid, and cinnamate. In addition to being an antioxidant, anti-inflammatory, antidiabetic, antimicrobial, anticancer, lipid-lowering, and cardiovascular-disease-lowering compound, cinnamon has also been reported to have activities against neurological disorders, such as Parkinson’s and Alzheimer’s diseases. This review illustrates the pharmacological prospective of cinnamon and its use in daily life.
The bark of various cinnamon species is one of the most important and popular spices used worldwide not only for cooking but also in traditional and modern medicines. Overall, approximately 250 species have been identified among the cinnamon genus, with trees being scattered all over the world [1, 2].
Cinnamon is mainly used in the aroma and essence industries due to its fragrance, which can be incorporated into different varieties of foodstuffs, perfumes, and medicinal products . The most important constituents of cinnamon are cinnamaldehyde and trans-cinnamaldehyde (Cin), which are present in the essential oil, thus contributing to the fragrance and to the various biological activities observed with cinnamon . A study on Cinnamomum osmophloeum (C. osmophloeum) indicated that the essential oil from cinnamon leaves contains a high level of Cin. Consequently, C. osmophloeum is also used as an alternative spice for C. cassia . One of the major constituents of essential oil extracted from C. zeylanicum named (E)-cinnamaldehyde has an antityrosinase activity , while cinnamaldehyde is the principal compound responsible for this activity .
Cinnamon bark contains procyanidins and catechins . The components of procyanidins include both procyanidin A-type and B-type linkages [9–11]. These procyanidins extracted from cinnamon and berries also possess antioxidant activities [10, 12].
The current review was conducted using a complete and organized search of the available literature on the medicinal plant cinnamon from 1982 to 2013. The searches were performed using various databases, including PubMed (http://www.ncbi.nlm.nih.gov/pubmed), Science Direct (http://www.sciencedirect.com/), Scopus (http://www.scopus.com/), Scirus (http://www.scirus.com/), and Google Scholar (http://www.scholar.google.com/).
3. Traditional Uses
In addition to being used as a spice and flavoring agent, cinnamon is also added to flavor chewing gums due to its mouth refreshing effects and ability to remove bad breath . Cinnamon can also improve the health of the colon, thereby reducing the risk of colon cancer .
Cinnamon is a coagulant and prevents bleeding . Cinnamon also increases the blood circulation in the uterus and advances tissue regeneration . This plant plays a vital role as a spice, but its essential oils and other constituents also have important activities, including antimicrobial [17–20], antifungal , antioxidant [22–26], and antidiabetic [27–33].
Cinnamon has been used as anti-inflammatory [34–36], antitermitic , nematicidal [37, 38], mosquito larvicidal , insecticidal , antimycotic, [40–43] and anticancer agent [44–47]. Cinnamon has also been traditionally used as tooth powder and to treat toothaches, dental problems, oral microbiota, and bad breath [48, 49].
4. Chemical Constituents
Cinnamon consists of a variety of resinous compounds, including cinnamaldehyde, cinnamate, cinnamic acid, and numerous essential oils  (Table 1). Singh et al.  reported that the spicy taste and fragrance are due to the presence of cinnamaldehyde and occur due to the absorption of oxygen. As cinnamon ages, it darkens in color, improving the resinous compounds . Sangal reported various physiochemical properties of cinnamon (Table 2). The presence of a wide range of essential oils, such as trans-cinnamaldehyde, cinnamyl acetate, eugenol, L-borneol, caryophyllene oxide, b-caryophyllene, L-bornyl acetate, E-nerolidol, α-cubebene, α-terpineol, terpinolene, and α-thujene, has been reported [35, 36].
5. Antioxidant Activity
Antioxidant compounds present in foodstuffs play a vital role in human life, acting as health-protecting agents. In addition to this role, antioxidants are one of the key additives used in fats and oils. Even in the food processing industry, antioxidants have been used to delay or prevent food spoilage. Spices and medicinal plants have received rapid consideration as sources of beneficial antioxidants against various diseases . Antioxidants have been considered the most important drivers in the progress and existence of humans, as they respond to free radicals and damage in metabolic diseases and age-related syndromes of humans and other animals [53, 54].
Mancini-Filho et al. reported various extracts of cinnamon, such as ether, aqueous, and methanolic extracts that have shown considerable antioxidant activities . A study on rats reported that the administration of the bark powderof C. verum (10%) for 90 days produced antioxidant activities as indicated by cardiac and hepatic antioxidant enzymes, lipid conjugate dienes, and glutathione (GSH) . A research group reported that cinnamon oil potentially exhibits superoxide-dismutase- (SOD-) like activity as indicated by the inhibition of the inhibiting capacity of pyrogallol autoxidation .
The aqueous and alcoholic extract (1 : 1) of cinnamon potentially significantly inhibits fatty acid oxidation and lipid peroxidation in vitro . Different flavonoids isolated from cinnamon have free-radical-scavenging activities and antioxidant properties . A study of the inhibitory effects of cinnamaldehyde and other compounds of cinnamon on nitric oxide production revealed that cinnamaldehyde possesses potential activity against the production of nitric oxide as well as the expression of inducible nitric oxide. The highest inhibitory activities were reported as 81.5%, 71.7%, and 41.2% at 1.0, 0.5, and 0.1 µg/µL, respectively . Lin et al. reported the in vivo antioxidant activity of two different extracts, the ethanolic and hot water extracts of the dry bark of C. cassia. The ethanolic extract of C. cassia exhibited significant inhibition (96.3%) compared to the natural antioxidant α-tocopherol (93.74%) . Overall, cinnamon exhibited higher antioxidant activities compared to that of other dessert spices .
The essential oils and some of the major compounds present in cinnamon, including (E)-cinnamaldehyde, eugenol, and linalool, were investigated in reference to peroxynitrite-induced nitration and lipid peroxidation. Eugenol and the essential oils were more effective than the other two compounds . In a comparative study among 26 spices, cinnamon showed the highest antioxidant activity, indicating that it can be applied as an antioxidant used in foods . Another study investigated the effectiveness of a mixture of spices on oxidative stress markers as well as the antioxidant activity in high fructose-fed insulin-resistant rats. The mixture, which consisted of 1 g/100 g cinnamon bark, showed a significant antioxidant activity compared to the fructose alone group . Volatile oils from C. zeylanicum showed significant biological activities .
Forty-one different volatile compounds in the bark oil of cinnamon have been identified and were found to vary significantly in percentage composition depending on the growth stages and segments of the C. cassia tree . To extract essential oil for industrial use, the yields and compositions of bark oil during Cinnamomum cassia growth (1–3 years old for the branch bark and 5–12 years old for the stem bark) were determined. These researchers also found that the branch bark fraction tended to yield more essential oil compared to the entire branch, indicating that selecting the bark based on the tree growth stages as well as separating the stem barks into top, center, and lower sections within a tree can significantly improve the extraction efficiency of essential oils.
A preliminary study on C. malabatrum leaves was conducted in various types of extracts (n-hexane, alcoholic, and aqueous extracts) to determine the presence of phenolic compounds, which indicate antioxidant activity. All of the extracts had moderate amounts of phenolic compounds and showed potential activity against hydrogen peroxide, nitric oxide, and lipid peroxide free radicals . A recent study investigated the antioxidant properties of several parts (i.e., the leaves, barks, and buds) of C. cassia. The ethanolic extract of all of the plant parts had significant antioxidant properties compared with the extraction using the supercritical fluid . The supercritical extracts showed decreased activity compared to the ethanol extracts, indicating that the active components are constituents with high polarity.
C. tamala has potential antioxidant activities in diabetic rats , while C. osmophloeum, a species from Taiwan, has significant in vitro and in vivo antioxidant activities under oxidative stress . The antioxidant activity of C. zeylanicum has been investigated using various methods. In addition to the antioxidant activity, cinnamon can be used as a preservative in cakes and other food products . A recent study reported that pectin film coated with cinnamon leaf extract yielded high antioxidant and antibacterial activities . Dong et al. reported that cinnamaldehyde (E) extracted from C. cassia is the main compound and is present in levels as high as 72.7% compared to other volatile components . Cinnamaldehyde (E) is well known for its antityrosinase activity [6, 73]. Currently, much attention is given to tyrosinase inhibitors due to their actions in suppressing hyperpigmentation as well as the unsightly browning effects observed in mushrooms, fruits, and vegetables when they are exposed to sunlight or air. Hence, antityrosinase agents are associated with a wide range of applications, such as cosmetics, medicine, and food [74, 75].
6. Anti-Inflammatory Activities
Several studies on medicinal plants and their components have indicated the anti-inflammatory activities of cinnamon [76–81]. Various studies reported the anti-inflammatory activity of cinnamon and its essential oils [34–36]. To date, there are several flavonoid compounds (e.g., gossypin, gnaphalin, hesperidin, hibifolin, hypolaetin, oroxindin, and quercetin) that have been isolated and have anti-inflammatory activities [82–86].
A recent study reported that 2′-hydroxycinnamaldehyde isolated from C. cassia bark exhibited an inhibitory effect on the production of nitric oxide by inhibiting the activation of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), indicating that this substance can potentially be used as an anti-inflammatory agent . The ethanolic extract of C. cassia showed significant anti-inflammatory effects by reducing the activation of Src/spleen-tyrosine-kinase- (Src/Syk-) mediated NF-κB [88, 89]. Various compounds contained in C. ramulus showed anti-inflammatory effects by suppressing the expression of inducible nitric oxide synthesis (iNOS), cyclooxygenase-2 (COX-2), and nitric oxide (NO) production in the central nervous system (CNS). By this mechanism, C. ramulus could be a potential source for the therapeutic treatment or prevention of inflammation-mediated neurodegenerative diseases . Furthermore, the aqueous extract of cinnamon decreases the lipopolysaccharide-induced tumor necrosis factor-α levels in the serum .
7. Neurological Disorders
Cinnamophilin is a novel thromboxane A2 receptor antagonist isolated from C. philippinensis . A study reported that cinnamophilin confers protection against ischemic damage in rat brains when administered at 80 mg/kg at different time intervals (2, 4, and 6 h) after insult. The effects were found to have a considerable effect (by 34–43%) on abridged brain infarction  and further enhance neurobehavioral outcomes. Cinnamophilin also dramatically condenses the oxygen glucose deprivation-induced neuronal damage in organotypic hippocampal slices in experimental rats. A substance called procyanidin type-A trimer (trimer 1) isolated from cinnamon’s water-soluble extract showed that trimer 1 may reduce cell swelling by controlling the movement of intracellular calcium [Ca2+]i . Trimer 1 also considerably alleviates the oxygen glucose deprivation-induced diminishing effects on glutamate uptake. The protective effects of trimer 1 in attenuating the diminution in glutamate uptake are possibly arbitrated via their effects on the mitochondria .
Parkinson’s disease (PD) is the second major widespread neurodegenerative disorder after Alzheimer’s disease, with a prevalence of 2% in people 65 years and older . PD protein 7 (PARK7) is an autosomal recessive form of early-onset parkinsonism caused by alterations in the DJ-1 gene . Khasnavis and Pahan reported that sodium benzoate, a cinnamon metabolite, upregulates DJ-1 by modulating mevalonate metabolites [97, 98]. Cinnamon and its metabolite sodium benzoate also upregulate the neurotropic factors BDNF (brain-derived neurotropic factors) as well as neurotrophin-3 (NT-3) in the mouse central nervous system . PARK7 is one of the main neuroprotective proteins that protects cells from damage and from the further detrimental effects of oxidative stress; therefore, this protein may be an effective molecule that can be incorporated into the therapeutic intervention of Parkinson’s disease .
A natural compound isolated from cinnamon extract (CEppt) significantly reduces the formation of toxic β-amyloid polypeptide (Aβ) oligomers and prevents its toxicity on neuronal pheochromocytoma (PC12) cells . The study indicated that CEppt resolved the reduced permanence, fully improved deficiencies in locomotion, and totally eradicated the tetrameric species of Aβ in the brain of the fly model of Alzheimer’s disease, leading to a noticeable reduction in the 56 kDa Aβ oligomers, reducing plaques and improving the cognitive performance of transgenic mice models .
Another study reported that the aqueous extract of C. zeylanicum can reduce tau aggregation and filament formation, two of the main features of Alzheimer's disease. The extract can also encourage the complete fragmentation of recombinant tau filaments and cause the considerable modification of the morphology of paired helical filaments from Alzheimer’s disease brain , indicating the potential of cinnamon in the treatment of Alzheimer’s disease.
8. Antidiabetic Activity
A substance from cinnamon has been isolated and coined as “insulin-potentiating factor” (IPF) , while the antidiabetic effects of cinnamon bark have been shown in streptozotocin-induced diabetic rats . Several studies have also revealed that cinnamon extracts lower not only blood glucose but also cholesterol levels [103–107].
A study comparing the insulin-potentiating effects of many spices revealed that the aqueous extract of cinnamon was 20-fold higher than the other spices . Methylhydroxychalcone polymer (MHCP) is the purified polymer of hydroxychalcone with the ability to stimulate glucose oxidation [30, 109]. Anderson et al. isolated and characterized the polyphenol type-A polymers from cinnamon and found that these substances act as insulin-like molecules . Following this characterization, a new compound from hydroxycinnamic acid derivatives named naphthalenemethyl ester, which has blood glucose-lowering effects, has been identified , further confirming cinnamon’s antidiabetic effects.
Several polyphenols have been isolated from cinnamon. These polyphenols include rutin (90.0672%), catechin (1.9%), quercetin (0.172%), kaempferol (0.016%), and isorhamnetin (0.103%) [67, 110]. Cao et al. (2007) demonstrated that the aqueous extract of cinnamon containing polyphenols purified by high performance liquid chromatography (HPLC) showed insulin-like activity . The aqueous extract of cinnamon markedly decreased the absorption of alanine in the rat intestine. Alanine plays a vital role in gluconeogenesis, is altered back to pyruvate in the liver, and is utilized as a substrate for gluconeogenesis . However, another study conducted on diabetic postmenopausal women supplemented with cinnamon showed poor glycemic control , even though cinnamon is generally believed to be useful for diabetes. However, it is plausible that differences in the dose of cinnamon used, as well as baseline glucose and lipid levels, have led to these variations.
In a recent study , suitable doses of cinnamon (5, 10, and 20 mg/kg) of the linalool chemotype were found to help with glycemic control in diabetics due to enhanced insulin secretion. It is plausible that the amelioration of oxidative stress and the proinflammatory environment in the pancreas may confer protection to pancreatic β cells , which should be further investigated.
9. Antimicrobial Activity
To date, several antimicrobial activities of cinnamon and its oils have been reported in various studies [20, 28, 115]. For example, Matan et al. reported the effects of cinnamon oils on different bacterial (Pediococcus halophilus and Staphylococcus aureus), fungal (Aspergillus flavus, Mucor plumbeus, Penicillium roqueforti, and Eurotium sp.), and yeast species (Candida lipolytica, Pichia membranaefaciens, Debaryomyces hansenii, and Zygosaccharomyces rouxii) , indicating that cinnamon is a natural antimicrobial agent.
Goñi et al. described the antibacterial activity of a combination of cinnamon and clove oils against Gram-positive organisms (Listeria monocytogenes, Enterococcus faecalis, Staphylococcus aureus, and Bacillus cereus), as well as against Gram-negative bacteria (Salmonella choleraesuis, Escherichia coli, Pseudomonas aeruginosa, and Yersinia enterocolitica) . A study from Hili et al. indicated that cinnamon oils have potential action against various bacteria (Pseudomonas aeruginosa, Staphylococcus aureus, and Escherichia coli) and yeast (Torulopsis utilis, Schizosaccharomyces pombe, Candida albicans, and Saccharomyces cerevisiae) . A recent study reported the activity of the aqueous extract of cinnamon and other plants against oral microflora. Overall, the essential oil from cinnamon is more potent than other tested plant extracts, such as Azadirachta indica and Syzygium aromaticum .
10. Anticancer Activity
The aqueous extract and the fraction of cinnamon (procyanidins) from HPLC inhibit vascular endothelial growth factor subtype 2 (VEGFR2) kinase activity, thereby inhibiting the angiogenesis involved in cancer. The results of the study revealed that cinnamon could potentially be used in cancer prevention . Cinnamaldehydes have been synthesized and tested as inhibitors against angiogenesis . Jeong et al. reported that CB403, a chemical that can be synthesized from 2′-hydroxycinnamaldehyde derived from cinnamaldehyde, can inhibit tumor growth. Overall, the antitumor and growth-inhibitory properties of CB403 in animal-based studies as well as in cell culture-based studies indicate the potential of cinnamon to be used as an anticancer agent .
Cabello et al. reported that cinnamic aldehyde inhibits the activity of NF-κB and the production of tumor necrosis factor alpha (TNFα-) induced interleukin-8 (IL-8) in A375 cells . This inhibition provides additional support to the existing unrecognized role of cinnamic acid as a potential anticancer agent . Fang and others reported the anticancer effect of trans-cinnamaldehyde from C. osmophloeum, finding that trans-cinnamaldehyde showed potential effects in restraining tumor cell growth and in enhancing tumor cell apoptosis .
A preliminary study on cinnamon and cardamom against azoxymethane- (AOM-) induced colon cancer in Swiss albino mice has been conducted . Treatments with the aqueous extracts of cinnamon and cardamom augment the activities of the detoxifying and antioxidant enzyme glutathione-s-transferase (GST) with a concomitant reduction in lipid peroxidation levels in animals with colon cancer compared to controls . The essential oils extracted from C. cassia inhibit alpha melanocyte-stimulating hormone’s induced melanin production, thereby suppressing oxidative stress in murine B16 melanoma cells .
11. Cardiovascular Diseases
One of the active components isolated from C. cassia named 2-methoxycinnamaldehyde (2-MCA) decreases the expression of vascular cell adhesion molecule-1 (VCAM-1) in TNFα-activated endothelial cells, suggesting that ischemia/reperfusion (I/R) injury is ameliorated due to the induction of hemeoxygenase- (HO-) 1 . A recent study reported the potential effects of two compounds, cinnamic aldehyde and cinnamic acid, isolated from C. cassia against myocardial ischemia , indicating that cinnamon also has the potential to be used to treat cardiovascular diseases.
Several studies have reported the protective effects of cinnamaldehyde on the cardiovascular system. Cinnamophilin is one of the important lignans isolated from C. philippinensis and has been confirmed to have thromboxane A2 (TXA2) receptor blocking activity in rats as well as in guinea pigs . Cinnamophilin acts as a potential thromboxane synthase inhibitor and TXA2 receptor antagonist and may be helpful when incorporated in the treatment of diseases involving TXA2 disorders , such as platelet aggregation  and cancers . Cinnamophilin mainly inhibits thromboxane receptor-mediated vascular smooth muscle cell proliferation and may have the potential for use in the prevention of vascular diseases and atherosclerosis .
Cinnamaldehyde produces hypotensive effects, which are possibly mainly due to peripheral vasodilatation in anesthetized dogs and guinea pigs . The vasodilatation induced by cinnamaldehyde in dogs lasted and remained over the recovery period of the fall in blood pressure to the baseline . A recent study showed that cinnamaldehyde expands rat vascular smooth muscle in an endothelium-independent manner. The ability of cinnamaldehyde in vasodilatory function may be because it impedes both Ca2+ influx and Ca2+ release . Cinnamaldehyde averts the progress of hypertension in types 1 and 2 diabetes by abridging vascular contractility, in addition to its insulinotropic effect in insulin deficiency .
12. Cholesterol- and Lipid-Lowering Effects
The administration of cinnamon to mice positively affected the lipid profile, whereby the high density lipoprotein (HDL) cholesterol levels decreased, and plasma triglycerides were reduced . Another study by  found a reduction in the total cholesterol, triglycerides, and low-density lipoproteins in rats administered Cinnamomum cassia powder (15%) for 35 days. Additionally, cinnamon oils reduced the cholesterol levels in broiler chickens . A study by Khan et al. reported that the administration of cinnamon at 1, 3, and 6 g doses per day caused a reduction in serum glucose, triglyceride, total cholesterol, and LDL cholesterol levels in humans .
13. Advanced Glycation End Products (AGEs)
Different types of phenolic and flavonoid compounds have been isolated from cinnamon. Epicatechin, catechin, and procyanidin B2, which are the phenolic compounds isolated from cinnamon, showed noteworthy and potentially inhibitory activities on the formation of AGEs. These antiglycation activities of the phenolic compounds not only are attributed to their antioxidant activities but also are associated with the entrapping capabilities of reactive carbonyl species, such as methylglyoxal (MGO), an intermediate reactive carbonyl of AGE formation [10, 135]. The inhibition of AGE formation by trapping the reactive carbonyl species could be a logical therapeutic approach to treat diabetes and its complications .
Cinnamon has been used as a spice in daily life without any side effects. Several reports have dealt with the numerous properties of cinnamon in the forms of bark, essential oils, bark powder, phenolic compounds, flavonoids, and isolated components. Each of these properties plays a key role in the advancement of human health. The antioxidant and antimicrobial activities may occur through the direct action on oxidants or microbes, whereas the anti-inflammatory, anticancer, and antidiabetic activities occur indirectly via receptor-mediated mechanisms. The significant health benefits of numerous types of cinnamon have been explored. Further investigations are necessary to provide additional clinical evidence for the traditional uses of this spice against cancer and inflammatory, cardioprotective, and neurological disorders.
|Src/Syk:||Src/spleen tyrosine kinase|
|iNOS:||Inducible nitric oxide synthesis|
|CNS:||Central nervous system|
|PARK7:||PD protein 7|
|PC 12:||Pheochromocytoma 12|
|VEGFR2:||Vascular endothelial growth factor subtype 2|
|TNFα:||Tumor necrosis factor-alpha interleukin-8 (IL-8)|
|VCAM-1:||Vascular cell adhesion molecule-1|
|HO:||Heme oxygenase (HO)|
|HDL cholesterol:||High-density lipoprotein cholesterol|
Conflict of Interests
The authors declare that there is no conflict of interests concerning this paper.
The corresponding author Dr. Pasupuleti Visweswara Rao expresses thanks to Mr. Balam Satheesh Krishna, Department of Chemistry, S. V. University, for the discussion and help in chemical structure related issues.
- A. Sangal, “Role of cinnamon as beneficial antidiabetic food adjunct: a review,” Advances in Applied Science Research, vol. 2, no. 4, pp. 440–450, 2011.
- M. Vangalapati, N. Sree Satya, D. Surya Prakash, and S. Avanigadda, “A review on pharmacological activities and clinical effects of cinnamon species,” Research Journal of Pharmaceutical, Biological and Chemical Sciences, vol. 3, no. 1, pp. 653–663, 2012.
- T.-C. Huang, H.-Y. Fu, C.-T. Ho, D. Tan, Y.-T. Huang, and M.-H. Pan, “Induction of apoptosis by cinnamaldehyde from indigenous cinnamon Cinnamomum osmophloeum Kaneh through reactive oxygen species production, glutathione depletion, and caspase activation in human leukemia K562 cells,” Food Chemistry, vol. 103, no. 2, pp. 434–443, 2007.
- H.-F. Yeh, C.-Y. Luo, C.-Y. Lin, S.-S. Cheng, Y.-R. Hsu, and S.-T. Chang, “Methods for thermal stability enhancement of leaf essential oils and their main Constituents from Indigenous Cinnamon (Cinnamomum osmophloeum),” Journal of Agricultural and Food Chemistry, vol. 61, no. 26, pp. 6293–6298, 2013.
- C.-W. Chang, W.-L. Chang, S.-T. Chang, and S.-S. Cheng, “Antibacterial activities of plant essential oils against Legionella pneumophila,” Water Research, vol. 42, no. 1-2, pp. 278–286, 2008.
- B. Marongiu, A. Piras, S. Porcedda et al., “Supercritical CO2 extract of Cinnamomum zeylanicum: chemical characterization and antityrosinase activity,” Journal of Agricultural and Food Chemistry, vol. 55, no. 24, pp. 10022–10027, 2007.
- S.-T. Chou, W.-L. Chang, C.-T. Chang, S.-L. Hsu, Y.-C. Lin, and Y. Shih, “Cinnamomum cassia Essential Oil inhibits α-MSH-induced melanin production and oxidative stress in murine B16 melanoma cells,” International Journal of Molecular Sciences, vol. 14, no. 9, pp. 19186–19201, 2013.
- G.-I. Nonaka, S. Morimoto, and I. Nishioka, “Tannins and related compounds. Part 13. Isolation and structures of trimeric, tetrameric, and pentameric proanthicyanidins from cinnamon,” Journal of the Chemical Society, Perkin Transactions 1, pp. 2139–2145, 1983.
- R. A. Anderson, C. L. Broadhurst, M. M. Polansky et al., “Isolation and characterization of polyphenol type-A polymers from cinnamon with insulin-like biological activity,” Journal of Agricultural and Food Chemistry, vol. 52, no. 1, pp. 65–70, 2004.
- X. Peng, K.-W. Cheng, J. Ma et al., “Cinnamon bark proanthocyanidins as reactive carbonyl scavengers to prevent the formation of advanced glycation endproducts,” Journal of Agricultural and Food Chemistry, vol. 56, no. 6, pp. 1907–1911, 2008.
- T. Tanaka, Y. Matsuo, Y. Yamada, and I. Kouno, “Structure of polymeric polyphenols of cinnamon bark deduced from condensation products of cinnamaldehyde with catechin and procyanidins,” Journal of Agricultural and Food Chemistry, vol. 56, no. 14, pp. 5864–5870, 2008.
- K. R. Määttä-Riihinen, M. P. Kähkönen, A. R. Törrönen, and I. M. Heinonen, “Catechins and procyanidins in berries of vaccinium species and their antioxidant activity,” Journal of Agricultural and Food Chemistry, vol. 53, no. 22, pp. 8485–8491, 2005.
- V. Jakhetia, R. Patel, P. Khatri, et al., “Cinnamon: a pharmacological review,” Journal of Advanced Scientific Research, vol. 1, no. 2, pp. 19–12, 2010.
- G. T. Wondrak, N. F. Villeneuve, S. D. Lamore, A. S. Bause, T. Jiang, and D. D. Zhang, “The cinnamon-derived dietary factor cinnamic aldehyde activates the Nrf2-dependent antioxidant response in human epithelial colon cells,” Molecules, vol. 15, no. 5, pp. 3338–3355, 2010.
- N. Hossein, Z. Zahra, M. Abolfazl, S. Mahdi, and K. Ali, “Effect of Cinnamon zeylanicum essence and distillate on the clotting time,” Journal of Medicinal Plants Research, vol. 7, no. 19, pp. 1339–1343, 2013.
- St. Minich and L. Msom, Chinese Herbal Medicine in Women’s Health, Women’s Health, 2008.
- S.-T. Chang, P.-F. Chen, and S.-C. Chang, “Antibacterial activity of leaf essential oils and their constituents from Cinnamomum osmophloeum,” Journal of Ethnopharmacology, vol. 77, no. 1, pp. 123–127, 2001.
- P. Hili, C. S. Evans, and R. G. Veness, “Antimicrobial action of essential oils: the effect of dimethylsulphoxide on the activity of cinnamon oil,” Letters in Applied Microbiology, vol. 24, no. 4, pp. 269–275, 1997.
- N. Matan, H. Rimkeeree, A. J. Mawson, P. Chompreeda, V. Haruthaithanasan, and M. Parker, “Antimicrobial activity of cinnamon and clove oils under modified atmosphere conditions,” International Journal of Food Microbiology, vol. 107, no. 2, pp. 180–185, 2006.
- L. B. Gende, I. Floris, R. Fritz, and M. J. Eguaras, “Antimicrobial activity of cinnamon (Cinnamomum zeylanicum) essential oil and its main components against paenibacillus larvae from argentine,” Bulletin of Insectology, vol. 61, no. 1, pp. 1–4, 2008.
- S.-Y. Wang, P.-F. Chen, and S.-T. Chang, “Antifungal activities of essential oils and their constituents from indigenous cinnamon (Cinnamomum osmophloeum) leaves against wood decay fungi,” Bioresource Technology, vol. 96, no. 7, pp. 813–818, 2005.
- J. Mancini-Filho, A. van-Koiij, D. A. P. Mancini, F. F. Cozzolino, and R. P. Torres, “Antioxidant activity of cinnamon (Cinnamomum zeylanicum, breyne) extracts,” Bollettino Chimico Farmaceutico, vol. 137, no. 11, pp. 443–447, 1998.
- S. Shobana and K. Akhilender Naidu, “Antioxidant activity of selected Indian spices,” Prostaglandins Leukotrienes and Essential Fatty Acids, vol. 62, no. 2, pp. 107–110, 2000.
- S. Mathew and T. E. Abraham, “Studies on the antioxidant activities of cinnamon (Cinnamomum verum) bark extracts, through various in vitro models,” Food Chemistry, vol. 94, no. 4, pp. 520–528, 2006.
- S. Mathew and T. E. Abraham, “In vitro antioxidant activity and scavenging effects of Cinnamomum verum leaf extract assayed by different methodologies,” Food and Chemical Toxicology, vol. 44, no. 2, pp. 198–206, 2006.
- N. Kim, H. Sung, and W. Kim, “Effect of solvents and some extraction conditions on antioxidant activity in cinnamon extracts,” Korean Journal of Food Science and Technology, vol. 25, no. 3, pp. 204–209, 1993.
- S. H. Kim, S. H. Hyun, and S. Y. Choung, “Anti-diabetic effect of cinnamon extract on blood glucose in db/db mice,” Journal of Ethnopharmacology, vol. 104, no. 1-2, pp. 119–123, 2006.
- S. Prabuseenivasan, M. Jayakumar, and S. Ignacimuthu, “In vitro antibacterial activity of some plant essential oils,” BMC Complementary and Alternative Medicine, vol. 6, article 39, 2006.
- Q. Jia, X. Liu, X. Wu et al., “Hypoglycemic activity of a polyphenolic oligomer-rich extract of Cinnamomum parthenoxylon bark in normal and streptozotocin-induced diabetic rats,” Phytomedicine, vol. 16, no. 8, pp. 744–750, 2009.
- K. J. Jarvill-Taylor, R. A. Anderson, and D. J. Graves, “A hydroxychalcone derived from cinnamon functions as a mimetic for insulin in 3T3-L1 adipocytes,” Journal of the American College of Nutrition, vol. 20, no. 4, pp. 327–336, 2001.
- Z. Lu, Q. Jia, R. Wang et al., “Hypoglycemic activities of A- and B-type procyanidin oligomer-rich extracts from different Cinnamon barks,” Phytomedicine, vol. 18, no. 4, pp. 298–302, 2011.
- P. Subash Babu, S. Prabuseenivasan, and S. Ignacimuthu, “Cinnamaldehyde—a potential antidiabetic agent,” Phytomedicine, vol. 14, no. 1, pp. 15–22, 2007.
- S. Onderoglu, S. Sozer, K. M. Erbil, R. Ortac, and F. Lermioglu, “The evaluation of long-term effects of cinnamon bark and olive leaf on toxicity induced by streptozotocin administration to rats,” Journal of Pharmacy and Pharmacology, vol. 51, no. 11, pp. 1305–1312, 1999.
- L. K. Chao, K.-F. Hua, H.-Y. Hsu, S.-S. Cheng, J.-Y. Liu, and S.-T. Chang, “Study on the Antiinflammatory activity of essential oil from leaves of Cinnamomum osmophloeum,” Journal of Agricultural and Food Chemistry, vol. 53, no. 18, pp. 7274–7278, 2005.
- Y.-T. Tung, M.-T. Chua, S.-Y. Wang, and S.-T. Chang, “Anti-inflammation activities of essential oil and its constituents from indigenous cinnamon (Cinnamomum osmophloeum) twigs,” Bioresource Technology, vol. 99, no. 9, pp. 3908–3913, 2008.
- Y.-T. Tung, P.-L. Yen, C.-Y. Lin, and S.-T. Chang, “Anti-inflammatory activities of essential oils and their constituents from different provenances of indigenous cinnamon (Cinnamomum osmophloeum) leaves,” Pharmaceutical Biology, vol. 48, no. 10, pp. 1130–1136, 2010.
- I.-K. Park, J.-Y. Park, K.-H. Kim et al., “Nematicidal activity of plant essential oils and components from garlic (Allium sativum) and cinnamon (Cinnamomum verum) oils against the pine wood nematode (Bursaphelenchus xylophilus),” Nematology, vol. 7, no. 5, pp. 767–774, 2005.
- J.-O. Kong, S.-M. Lee, Y.-S. Moon, S.-G. Lee, and Y.-J. Ahn, “Nematicidal activity of cassia and cinnamon oil compounds and related compounds toward Bursaphelenchus xylophilus (Nematoda: Parasitaphelenchidae),” Journal of Nematology, vol. 39, no. 1, pp. 31–36, 2007.
- S.-S. Cheng, J.-Y. Liu, K.-H. Tsai, W.-J. Chen, and S.-T. Chang, “Chemical composition and mosquito larvicidal activity of essential oils from leaves of different Cinnamomum osmophloeum provenances,” Journal of Agricultural and Food Chemistry, vol. 52, no. 14, pp. 4395–4400, 2004.
- S.-S. Cheng, J.-Y. Liu, C.-G. Huang, Y.-R. Hsui, W.-J. Chen, and S.-T. Chang, “Insecticidal activities of leaf essential oils from Cinnamomum osmophloeum against three mosquito species,” Bioresource Technology, vol. 100, no. 1, pp. 457–464, 2009.
- V. Dhulasavant, S. Shinde, M. Pawar, and N. S. Naikwade, “Antihyperlipidemic activity of Cinnamomum tamala Nees. on high cholesterol diet induced Hyperlipidemia,” International Journal of PharmTech Research, vol. 2, no. 4, pp. 2517–2521, 2010.
- K. A. Amin and T. M. A. El-Twab, “Oxidative markers, nitric oxide and homocysteine alteration in hypercholesterolimic rats: role of atorvastatine and cinnamon,” International Journal of Clinical and Experimental Medicine, vol. 2, no. 3, pp. 254–265, 2009.
- T. Bandara, I. Uluwaduge, and E. R. Jansz, “Bioactivity of cinnamon with special emphasis on diabetes mellitus: a review,” International Journal of Food Sciences and Nutrition, vol. 63, no. 3, pp. 380–386, 2012.
- J. Lu, K. Zhang, S. Nam, R. A. Anderson, R. Jove, and W. Wen, “Novel angiogenesis inhibitory activity in cinnamon extract blocks VEGFR2 kinase and downstream signaling,” Carcinogenesis, vol. 31, no. 3, pp. 481–488, 2010.
- H.-K. Kwon, W. K. Jeon, J.-S. Hwang et al., “Cinnamon extract suppresses tumor progression by modulating angiogenesis and the effector function of CD8+ T cells,” Cancer Letters, vol. 278, no. 2, pp. 174–182, 2009.
- H.-K. Kwon, J.-S. Hwang, J.-S. So et al., “Cinnamon extract induces tumor cell death through inhibition of NFκB and AP1,” BMC Cancer, vol. 10, no. 1, article 392, 2010.
- S. J. Koppikar, A. S. Choudhari, S. A. Suryavanshi, S. Kumari, S. Chattopadhyay, and R. Kaul-Ghanekar, “Aqueous Cinnamon Extract (ACE-c) from the bark of Cinnamomum cassia causes apoptosis in human cervical cancer cell line (SiHa) through loss of mitochondrial membrane potential,” BMC Cancer, vol. 10, no. 1, article 210, 2010.
- K. Aneja, R. Joshi, and C. Sharma, “Antimicrobial activity of dalchini (Cinnamomum zeylanicum bark) extracts on some dental caries pathogens,” Journal of Pharmacy Research, vol. 2, no. 9, pp. 1387–1390, 2009.
- C. Gupta, A. Kumari, A. P. Garg, R. Catanzaro, and F. Marotta, “Comparative study of cinnamon oil and clove oil on some oral microbiota,” Acta Bio-Medica: Atenei Parmensis, vol. 82, no. 3, article 197, 2011.
- U. M. Senanayake, T. H. Lee, and R. B. H. Wills, “Volatile constituents of cinnamon (Cinnamomum zeylanicum) oils,” Journal of Agricultural and Food Chemistry, vol. 26, no. 4, pp. 822–824, 1978.
- G. Singh, S. Maurya, M. P. deLampasona, and C. A. N. Catalan, “A comparison of chemical, antioxidant and antimicrobial studies of cinnamon leaf and bark volatile oils, oleoresins and their constituents,” Food and Chemical Toxicology, vol. 45, no. 9, pp. 1650–1661, 2007.
- M. Suhaj, “Spice antioxidants isolation and their antiradical activity: a review,” Journal of Food Composition and Analysis, vol. 19, no. 6-7, pp. 531–537, 2006.
- B. Halliwell, “Free radicals and antioxidants—quo vadis?” Trends in Pharmacological Sciences, vol. 32, no. 3, pp. 125–130, 2011.
- B. Halliwell, “Reactive species and antioxidants. Redox biology is a fundamental theme of aerobic life,” Plant Physiology, vol. 141, no. 2, pp. 312–322, 2006.
- J. N. Dhuley, “Anti-oxidant effects of cinnamon (Cinnamomum verum) bark and greater cardamon (Amomum subulatum) seeds in rats fed high fat diet,” Indian Journal of Experimental Biology, vol. 37, no. 3, pp. 238–242, 1999.
- S. J. Kim, D. Han, K. D. Moon, and J. S. Rhee, “Measurement of superoxide dismutase-like activity of natural antioxidants,” Bioscience, Biotechnology, and Biochemistry, vol. 59, no. 5, pp. 822–826, 1995.
- M. Okawa, J. Kinjo, T. Nohara, and M. Ono, “DPPH (1,1-diphenyl-2-Picrylhydrazyl) radical scavenging activity of flavonoids obtained from some medicinal plants,” Biological and Pharmaceutical Bulletin, vol. 24, no. 10, pp. 1202–1205, 2001.
- H.-S. Lee, B.-S. Kim, and M.-K. Kim, “Suppression effect of Cinnamomum cassia bark-derived component on nitric oxide synthase,” Journal of Agricultural and Food Chemistry, vol. 50, no. 26, pp. 7700–7703, 2002.
- C.-C. Lin, S.-J. Wu, C.-H. Chang, and L.-T. Ng, “Antioxidant activity of Cinnamomum cassia,” Phytotherapy Research, vol. 17, no. 7, pp. 726–730, 2003.
- M. A. Murcia, I. Egea, F. Romojaro, P. Parras, A. M. Jiménez, and M. Martínez-Tomé, “Antioxidant evaluation in dessert spices compared with common food additives. Influence of irradiation procedure,” Journal of Agricultural and Food Chemistry, vol. 52, no. 7, pp. 1872–1881, 2004.
- S. Chericoni, J. M. Prieto, P. Iacopini, P. Cioni, and I. Morelli, “In vitro activity of the essential oil of Cinnamomum zeylanicum and eugenol in peroxynitrite-induced oxidative processes,” Journal of Agricultural and Food Chemistry, vol. 53, no. 12, pp. 4762–4765, 2005.
- B. Shan, Y. Z. Cai, M. Sun, and H. Corke, “Antioxidant capacity of 26 spice extracts and characterization of their phenolic constituents,” Journal of Agricultural and Food Chemistry, vol. 53, no. 20, pp. 7749–7759, 2005.
- R. Suganthi, S. Rajamani, M. K. Ravichandran, and C. V. Anuradha, “Effect of food seasoning spices mixture on biomarkers of oxidative stress in tissues of fructose-fed insulin-resistant rats,” Journal of Medicinal Food, vol. 10, no. 1, pp. 149–153, 2007.
- G. K. Jayaprakasha and L. J. M. Rao, “Chemistry, biogenesis, and biological activities of Cinnamomum zeylanicum,” Critical Reviews in Food Science and Nutrition, vol. 51, no. 6, pp. 547–562, 2011.
- S. Geng, Z. Cui, X. Huang, Y. Chen, D. Xu, and P. Xiong, “Variations in essential oil yield and composition during Cinnamomum cassia bark growth,” Industrial Crops and Products, vol. 33, no. 1, pp. 248–252, 2011.
- R. Aravind, T. Aneesh, A. Bindu, and K. Bindu, “Estimation of phenolics and evaluation of antioxidant activity of Cinnamomum malabatrum (Burm. F). Blume,” Asian Journal of Research in Chemistry, vol. 5, no. 5, pp. 628–632, 2012.
- C.-H. Yang, R.-X. Li, and L.-Y. Chuang, “Antioxidant activity of various parts of Cinnamomum cassia extracted with different extraction methods,” Molecules, vol. 17, no. 6, pp. 7294–7304, 2012.
- S. Kumar, N. Vasudeva, and S. Sharma, “GC-MS analysis and screening of antidiabetic, antioxidant and hypolipidemic potential of Cinnamomum tamala oil in streptozotocin induced diabetes mellitus in rats,” Cardiovascular Diabetology, vol. 11, no. 1, pp. 1–11, 2012.
- F.-L. Hsu, W.-H. Li, C.-W. Yu et al., “In vivo antioxidant activities of essential oils and their constituents from leaves of the Taiwanese Cinnamomum osmophloeum,” Journal of Agricultural and Food Chemistry, vol. 60, no. 12, pp. 3092–3097, 2012.
- H. Kordsardouei, M. Barzegar, and M. A. Sahari, “Application of Zataria multiflora Boiss. and Cinnamon zeylanicum essential oils as two natural preservatives in cake,” Avicenna Journal of Phytomedicine, vol. 3, no. 3, pp. 238–247, 2013.
- J. F. Ayala-Zavala, B. Silva-Espinoza, M. Cruz-Valenzuela, et al., “Pectin-cinnamon leaf oil coatings add antioxidant and antibacterial properties to fresh-cut peach,” Flavour and Fragrance Journal, vol. 28, no. 1, pp. 39–45, 2013.
- Y. Dong, N. Lu, and R. B. Cole, “Analysis of the volatile organic compounds in Cinnamomum cassia bark by direct sample introduction thermal desorption gas chromatography-mass spectrometry,” Journal of Essential Oil Research, vol. 25, no. 6, pp. 458–463, 2013.
- Y. Shi, Q.-X. Chen, Q. Wang, K.-K. Song, and L. Qiu, “Inhibitory effects of cinnamic acid and its derivatives on the diphenolase activity of mushroom (Agaricus bisporus) tyrosinase,” Food Chemistry, vol. 92, no. 4, pp. 707–712, 2005.
- L. Georgiev, M. Chochkova, I. Totseva, et al., “Anti-tyrosinase, antioxidant and antimicrobial activities of hydroxycinnamoylamides,” Medicinal Chemistry Research, vol. 22, no. 9, pp. 4173–4182, 2013.
- S. Parvez, M. Kang, H.-S. Chung, and H. Bae, “Naturally occurring tyrosinase inhibitors: mechanism and applications in skin health, cosmetics and agriculture industries,” Phytotherapy Research, vol. 21, no. 9, pp. 805–816, 2007.
- J. Lin, A. R. Opoku, M. Geheeb-Keller et al., “Preliminary screening of some traditional zulu medicinal plants for anti-inflammatory and anti-microbial activities,” Journal of Ethnopharmacology, vol. 68, no. 1–3, pp. 267–274, 1999.
- N. Mascolo, F. Capasso, A. Menghini, and M. P. Fasulo, “Biological screening of Italian medicinal plants for anti-inflammatory activity,” Phytotherapy Research, vol. 1, no. 1, pp. 28–31, 1987.
- H. Tunón, C. Olavsdotter, and L. Bohlin, “Evaluation of anti-inflammatory activity of some Swedish medicinal plants. Inhibition of prostaglandin biosynthesis and PAF-induced exocytosis,” Journal of Ethnopharmacology, vol. 48, no. 2, pp. 61–76, 1995.
- R. W. Li, G. David Lin, S. P. Myers, and D. N. Leach, “Anti-inflammatory activity of Chinese medicinal vine plants,” Journal of Ethnopharmacology, vol. 85, no. 1, pp. 61–67, 2003.
- S. Sosa, M. J. Balick, R. Arvigo et al., “Screening of the topical anti-inflammatory activity of some Central American plants,” Journal of Ethnopharmacology, vol. 81, no. 2, pp. 211–215, 2002.
- E. N. Matu and J. van Staden, “Antibacterial and anti-inflammatory activities of some plants used for medicinal purposes in Kenya,” Journal of Ethnopharmacology, vol. 87, no. 1, pp. 35–41, 2003.
- A. García-Lafuente, E. Guillamón, A. Villares, M. A. Rostagno, and J. A. Martínez, “Flavonoids as anti-inflammatory agents: implications in cancer and cardiovascular disease,” Inflammation Research, vol. 58, no. 9, pp. 537–552, 2009.
- H. P. Kim, K. H. Son, H. W. Chang, and S. S. Kang, “Anti-inflammatory plant flavonoids and cellular action mechanisms,” Journal of Pharmacological Sciences, vol. 96, no. 3, pp. 229–245, 2004.
- T. Guardia, A. E. Rotelli, A. O. Juarez, and L. E. Pelzer, “Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rat,” Farmaco, vol. 56, no. 9, pp. 683–687, 2001.
- G. Stoner and L.-S. Wang, “Natural products as anti-inflammatory agents,” in Obesity, Inflammation and Cancer, pp. 341–361, Springer, 2013.
- N. Cho, K. Y. Lee, J. Huh, et al., “Cognitive-enhancing effects of Rhus verniciflua bark extract and its active flavonoids with neuroprotective and anti-inflammatory activities,” Food and Chemical Toxicology, vol. 58, pp. 355–361, 2013.
- S. H. Lee, S. Y. Lee, D. J. Son et al., “Inhibitory effect of 2′-hydroxycinnamaldehyde on nitric oxide production through inhibition of NF-κB activation in RAW 264.7 cells,” Biochemical Pharmacology, vol. 69, no. 5, pp. 791–799, 2005.
- T. Yu, S. Lee, W. S. Yang et al., “The ability of an ethanol extract of Cinnamomum cassia to inhibit Src and spleen tyrosine kinase activity contributes to its anti-inflammatory action,” Journal of Ethnopharmacology, vol. 139, no. 2, pp. 566–573, 2012.
- H. S. Youn, J. K. Lee, Y. J. Choi et al., “Cinnamaldehyde suppresses toll-like receptor 4 activation mediated through the inhibition of receptor oligomerization,” Biochemical Pharmacology, vol. 75, no. 2, pp. 494–502, 2008.
- S.-H. Hwang, Y. G. Choi, M.-Y. Jeong, Y.-M. Hong, J.-H. Lee, and S. Lim, “Microarray analysis of gene expression profile by treatment of Cinnamomi ramulus in lipopolysaccharide-stimulated BV-2 cells,” Gene, vol. 443, no. 1-2, pp. 83–90, 2009.
- J.-W. Hong, G.-E. Yang, Y. B. Kim, S. H. Eom, J.-H. Lew, and H. Kang, “Anti-inflammatory activity of cinnamon water extract in vivo and in vitro LPS-induced models,” BMC Complementary and Alternative Medicine, vol. 12, no. 1, article 237, 2012.
- S.-M. Yu, F.-N. Ko, T.-S. Wu, J.-Y. Lee, and C.-M. Teng, “Cinnamophilin, a novel thromboxane A2 receptor antagonist, isolated from Cinnamomum philippinense,” European Journal of Pharmacology, vol. 256, no. 1, pp. 85–91, 1994.
- E.-J. Lee, H.-Y. Chen, Y.-C. Hung et al., “Therapeutic window for cinnamophilin following oxygen-glucose deprivation and transient focal cerebral ischemia,” Experimental Neurology, vol. 217, no. 1, pp. 74–83, 2009.
- K. S. Panickar, M. M. Polansky, D. J. Graves, J. F. Urban, and R. A. Anderson, “A procyanidin type A trimer from cinnamon extract attenuates glial cell swelling and the reduction in glutamate uptake following ischemia-like injury in vitro,” Neuroscience, vol. 202, pp. 87–98, 2012.
- M. C. de Rijk, L. J. Launer, K. Berger et al., “Prevalence of Parkinson's disease in Europe: a collaborative study of population-based cohorts,” Neurology, vol. 54, no. 11, supplement 5, pp. S21–S23, 2000.
- V. Bonifati, B. A. Oostra, and P. Heutink, “Linking DJ-1 to neurodegeneration offers novel insights for understanding the pathogenesis of Parkinson's disease,” Journal of Molecular Medicine, vol. 82, no. 3, pp. 163–174, 2004.
- S. Brahmachari, A. Jana, and K. Pahan, “Sodium benzoate, a metabolite of cinnamon and a food additive, reduces microglial and astroglial inflammatory responses,” The Journal of Immunology, vol. 183, no. 9, pp. 5917–5927, 2009.
- S. Khasnavis and K. Pahan, “Sodium benzoate, a metabolite of cinnamon and a food additive, upregulates neuroprotective parkinson disease protein DJ-1 in astrocytes and neurons,” Journal of Neuroimmune Pharmacology, vol. 7, no. 2, pp. 424–435, 2012.
- A. Jana, K. K. Modi, A. Roy, J. A. Anderson, R. B. van Breemen, and K. Pahan, “Up-regulation of neurotrophic factors by cinnamon and its metabolite sodium benzoate: therapeutic implications for neurodegenerative disorders,” Journal of Neuroimmune Pharmacology, vol. 8, no. 3, pp. 739–755, 2013.
- A. Frydman-Marom, A. Levin, D. Farfara et al., “Orally administrated cinnamon extract reduces β-amyloid oligomerization and corrects cognitive impairment in Alzheimer's disease animal models,” PLoS ONE, vol. 6, no. 1, Article ID e16564, 2011.
- D. W. Peterson, R. C. George, F. Scaramozzino et al., “Cinnamon extract inhibits tau aggregation associated with alzheimer's disease in vitro,” Journal of Alzheimer's Disease, vol. 17, no. 3, pp. 585–597, 2009.
- A. Khan, N. A. Bryden, M. M. Polansky, and R. A. Anderson, “Insulin potentiating factor and chromium content of selected foods and spices,” Biological Trace Element Research, vol. 24, no. 3, pp. 183–188, 1990.
- S. M. Blevins, M. J. Leyva, J. Brown, J. Wright, R. H. Scofield, and C. E. Aston, “Effect of cinnamon on glucose and lipid levels in non-insulin-dependent type 2 diabetes,” Diabetes Care, vol. 30, no. 9, pp. 2236–2237, 2007.
- A. Khan, M. Safdar, M. M. A. Khan, K. N. Khattak, and R. A. Anderson, “Cinnamon improves glucose and lipids of people with type 2 diabetes,” Diabetes Care, vol. 26, no. 12, pp. 3215–3218, 2003.
- B. Mang, M. Wolters, B. Schmitt et al., “Effects of a cinnamon extract on plasma glucose, HbA1c, and serum lipids in diabetes mellitus type 2,” European Journal of Clinical Investigation, vol. 36, no. 5, pp. 340–344, 2006.
- P. Crawford, “Effectiveness of cinnamon for lowering hemoglobin A1C in patients with type 2 diabetes: a randomized, controlled trial,” The Journal of the American Board of Family Medicine, vol. 22, no. 5, pp. 507–512, 2009.
- M. Safdar, A. Khan, M. M. A. K. Khattak, and M. Siddique, “Effect of various doses of cinnamon on blood glucose in diabetic individuals,” Pakistan Journal of Nutrition, vol. 3, no. 5, pp. 268–272, 2004.
- C. L. Broadhurst, M. M. Polansky, and R. A. Anderson, “Insulin-like biological activity of culinary and medicinal plant aqueous extracts in vitro,” Journal of Agricultural and Food Chemistry, vol. 48, no. 3, pp. 849–852, 2000.
- R. A. Anderson, C. L. Broadhurst, and M. M. Polansky, “Isolation and characterization of chalcone polymers from cinnamon with insulin like biological activities,” American Journal of Clinical Nutrition, vol. 84, no. 3, pp. 1432–1436, 2006.
- H.-B. Li, C.-C. Wong, K.-W. Cheng, and F. Chen, “Antioxidant properties in vitro and total phenolic contents in methanol extracts from medicinal plants,” LWT-Food Science and Technology, vol. 41, no. 3, pp. 385–390, 2008.
- H. Cao, M. M. Polansky, and R. A. Anderson, “Cinnamon extract and polyphenols affect the expression of tristetraprolin, insulin receptor, and glucose transporter 4 in mouse 3T3-L1 adipocytes,” Archives of Biochemistry and Biophysics, vol. 459, no. 2, pp. 214–222, 2007.
- S. I. Kreydiyyeh, J. Usta, and R. Copti, “Effect of cinnamon, clove and some of their constituents on the Na+ -K+ -ATPase activity and alanine absorption in the rat jejunum,” Food and Chemical Toxicology, vol. 38, no. 9, pp. 755–762, 2000.
- K. Vanschoonbeek, B. J. W. Thomassen, J. M. Senden, W. K. W. H. Wodzig, and L. J. C. van Loon, “Cinnamon supplementation does not improve glycemic control in postmenopausal type 2 diabetes patients,” The Journal of Nutrition, vol. 136, no. 4, pp. 977–980, 2006.
- S.-C. Lee, W.-X. Xu, L.-Y. Lin, J.J.. Yang, and C.-T. Liu, “Chemical composition and hypoglycemic and pancreas-protective effect of leaf essential oil from indigenous cinnamon (Cinnamomum osmophloeum Kanehira),” Journal of Agricultural and Food Chemistry, vol. 61, no. 20, pp. 4905–4913, 2013.
- R. Becerril, R. Gómez-Lus, P. Goñi, P. López, and C. Nerín, “Combination of analytical and microbiological techniques to study the antimicrobial activity of a new active food packaging containing cinnamon or oregano against E. coli and S. aureus,” Analytical and Bioanalytical Chemistry, vol. 388, no. 5-6, pp. 1003–1011, 2007.
- P. Goñi, P. López, C. Sánchez, R. Gómez-Lus, R. Becerril, and C. Nerín, “Antimicrobial activity in the vapour phase of a combination of cinnamon and clove essential oils,” Food Chemistry, vol. 116, no. 4, pp. 982–989, 2009.
- H. Parthasarathy and S. Thombare, “Evaluation of antimicrobial activity of Azadirachta indica, Syzygium aromaticum and Cinnamomum zeyalnicumagainst oral microflora,” Asian Journal of Experimental Sciences, vol. 27, no. 2, pp. 13–16, 2013.
- B.-M. Kwon, S.-H. Lee, Y.-K. Cho et al., “Synthesis and biological activity of cinnamaldehydes as angiogenesis inhibitors,” Bioorganic and Medicinal Chemistry Letters, vol. 7, no. 19, pp. 2473–2476, 1997.
- H.-W. Jeong, D. C. Han, K.-H. Son et al., “Antitumor effect of the cinnamaldehyde derivative CB403 through the arrest of cell cycle progression in the G2/M phase,” Biochemical Pharmacology, vol. 65, no. 8, pp. 1343–1350, 2003.
- C. M. Cabello, W. B. Bair III, S. D. Lamore et al., “The cinnamon-derived Michael acceptor cinnamic aldehyde impairs melanoma cell proliferation, invasiveness, and tumor growth,” Free Radical Biology and Medicine, vol. 46, no. 2, pp. 220–231, 2009.
- S.-H. Fang, Y. K. Rao, and Y.-M. Tzeng, “Cytotoxic effect of trans-cinnamaldehyde from cinnamomum osmophloeum leaves on Human cancer cell lines,” International Journal of Applied Science and Engineering, vol. 2, no. 2, pp. 136–147, 2004.
- S. Bhattacharjee, T. Rana, and A. Sengupta, “Inhibition of lipid peroxidation and enhancement of GST activity by cardamom and cinnamon during chemically induced colon carcinogenesis in Swiss albino mice,” Asian Pacific Journal of Cancer Prevention, vol. 8, no. 4, pp. 578–582, 2007.
- J. S. Hwa, Y. C. Jin, Y. S. Lee et al., “2-Methoxycinnamaldehyde from Cinnamomum cassia reduces rat myocardial ischemia and reperfusion injury in vivo due to HO-1 induction,” Journal of Ethnopharmacology, vol. 139, no. 2, pp. 605–615, 2012.
- F. Song, H. Li, J. Sun, and S. Wang, “Protective effects of cinnamic acid and cinnamic aldehyde on isoproterenol-induced acute myocardial ischemia in rats,” Journal of Ethnopharmacology, vol. 150, no. 1, pp. 125–130, 2013.
- S.-M. Yu, T.-S. Wu, and C.-M. Teng, “Pharmacological characterization of cinnamophilin, a novel dual inhibitor of thromboxane synthase and thromboxane A2 receptor,” British Journal of Pharmacology, vol. 111, no. 3, pp. 906–912, 1994.
- P. Jurasz, D. Alonso-Escolano, and M. W. Radomski, “Platelet-cancer interactions: mechanisms and pharmacology of tumour cell-induced platelet aggregation,” British Journal of Pharmacology, vol. 143, no. 7, pp. 819–826, 2004.
- D. Nie, M. Che, A. Zacharek et al., “Differential expression of thromboxane synthase in prostate carcinoma: role in tumor cell motility,” The American Journal of Pathology, vol. 164, no. 2, pp. 429–439, 2004.
- F.-N. Ko, S.-M. Yu, Y.-F. Kang, and C.-M. Teng, “Characterization of the thromboxane (TP-) receptor subtype involved in proliferation in cultured vascular smooth muscle cells of rat,” British Journal of Pharmacology, vol. 116, pp. 1801–1808, 1995.
- M. Harada and S. Yano, “Pharmacological studies on Chinese cinnamon. II. Effects of cinnamaldehyde on the cardiovascular and digestive systems,” Chemical and Pharmaceutical Bulletin, vol. 23, no. 5, pp. 941–947, 1975.
- M. Harada, Y. Hirayama, and R. Yamazaki, “Pharmacological studies on Chinese cinnamon. V. Catecholamine releasing effect of cinnamaldehyde in dogs,” Journal of Pharmacobio-Dynamics, vol. 5, no. 8, pp. 539–546, 1982.
- Y.-L. Xue, H.-X. Shi, F. Murad, and K. Bian, “Vasodilatory effects of cinnamaldehyde and its mechanism of action in the rat aorta,” Vascular health and risk management, vol. 7, pp. 273–280, 2011.
- H. M. El-Bassossy, A. Fahmy, and D. Badawy, “Cinnamaldehyde protects from the hypertension associated with diabetes,” Food and Chemical Toxicology, vol. 49, no. 11, pp. 3007–3012, 2011.
- S. Rahman, H. Begum, Z. Rahman, F. Ara, M. J. Iqbal, and A. K. M. Yousuf, “Effect of cinnamon (Cinnamomum cassia) as a lipid lowering agent on hypercholesterolemic rats,” Journal of Enam Medical College, vol. 3, no. 2, pp. 94–98, 2013.
- M. Ciftci, U. G. Simsek, A. Yuce, O. Yilmaz, and B. Dalkilic, “Effects of dietary antibiotic and cinnamon oil supplementation on antioxidant enzyme activities, cholesterol levels and fatty acid compositions of serum and meat in broiler chickens,” Acta Veterinaria Brno, vol. 79, no. 1, pp. 33–40, 2010.
- X. Peng, J. Ma, J. Chao et al., “Beneficial effects of cinnamon proanthocyanidins on the formation of specific advanced glycation endproducts and methylglyoxal-induced impairment on glucose consumption,” Journal of Agricultural and Food Chemistry, vol. 58, no. 11, pp. 6692–6696, 2010.
- G. K. Jayaprakasha, L. J. Rao, and K. K. Sakariah, “Chemical composition of volatile oil from Cinnamomum zeylanicum buds,” Zeitschrift fur Naturforschung C Journal of Biosciences, vol. 57, no. 11-12, pp. 990–993, 2002.