Novel Antidepressant-Like Activity of Caffeic Acid Phenethyl Ester Is Mediated by Enhanced Glucocorticoid Receptor Function in the Hippocampus

Figure 1

Effects of CAPE on depression-like behaviors during the TST and FST. (a) Experimental schematic of the antidepressant-like activity of CAPE. Mice were subjected to chronic unpredictable stress (CUS) for 21 consecutive days following intraperitoneal injection with vehicle (VEH), CAPE (5, 10, and 20 μmol/kg), or fluoxetine (FLX, 10 mg/kg). Body weight was measured prior to the behavioral test (b). Time spent immobile was recorded during the TST (c) and FST (d). The columns and error bars represent means ± SEM ( per group). Data were analyzed using a one-way ANOVA, followed by Tukey’s post hoc test. , , and versus VEH.

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