Novel Antidepressant-Like Activity of Caffeic Acid Phenethyl Ester Is Mediated by Enhanced Glucocorticoid Receptor Function in the Hippocampus

Figure 4

Differential effect of CAPE on MAPK phosphorylation in the hippocampus. Representative Western blot images (upper panel) depicting the expression of phosphorylation of (a) ERK, (b) JNK, and (c) p38MAPK in hippocampal lysates. Average band intensities (lower panel) were normalized to the corresponding nonphosphorylated MAPKs. The columns and error bars represent means ± SEM ( per group). Data were analyzed using a one-way ANOVA followed by Tukey’s post hoc test. versus VEH.

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