Red Sea Suberea mollis Sponge Extract Protects against CCl4-Induced Acute Liver Injury in Rats via an Antioxidant Mechanism
Figure 6
Histopathological study of liver tissue in control, CCl4, silymarin, and Suberea mollis sponge extract (SMSE) groups of rats. (a) Control group showed normal liver architecture. (b, c, and d) CCl4 group: (b) showed portal areas with dilated congested vein (PV) and proliferating bile ducts (arrows) and inflammatory cells. Notice fatty infiltration of hepatocytes (white arrow). (c) revealed cell necrosis (stars) near central veins (CV) with fibrous bridging (thin arrows). (d) showed increased dark degenerated apoptotic hepatocytes (black arrows) and fatty infiltration (white arrow). (e) CCl4 + silymarin (100 mg/kg) showed normal hepatocytes around the central vein with an absence of fatty infiltration. Few cells showed karyomegaly and dark degenerated nuclei (black arrow). (f) CCl4 + SMSE (100 mg/kg) showed normal hepatocytes around the central vein (CV) with few cells showing karyomegaly (red arrows). Blood sinusoids showed lymphocyte (dotted arrows) infiltration. Mild perivenular fibrosis (star) could be seen. (g) CCl4 + SMSE (200 mg/kg) showed normal hepatocytes (black arrows) with no signs of fatty changes around the central vein (CV) and mild perivenular fibrosis (star). (h) CCl4 + SMSE (400 mg/kg): region near central vein (CV) showed normal hepatocytes with an absence of any signs of fatty infiltration. Absence of perivenular fibrosis (H&E stain).
