Red Sea Suberea mollis Sponge Extract Protects against CCl₄-Induced Acute Liver Injury in Rats via an Antioxidant Mechanism

Table 1

Effects of the Suberea mollis sponge extract (SMSE) and silymarin on ALT, AST, ALK, and total bilirubin levels measured in CCl₄-induced hepatotoxicity in rats.

Treatment regimen	ALT	AST	ALP	Total bilirubin
Control	44.2 ± 5.89	145.8 ± 13.08	123.6 ± 24.35	1.2 ± 0.45
CCl4	161.8 ± 13.71^a	229.6 ± 19.48^a	312.6 ± 49.06^a	2.72 ± 0.19^a
CCl4 + silymarin (100 mg/kg)	63.5 ± 18.59^b	161 ± 29.8^b	148.75 ± 37.6^b	1.32 ± 0.12^b
CCl4 + SMSE (100 mg/kg)	85.25 ± 15.2^b	200.5 ± 34.8	219.5 ± 41.34^b	1.57 ± 0.3^b
CCl4 + SMSE (200 mg/kg)	71 ± 13.31^b	169.7 ± 37.52^b	182 ± 16.58^b	1.27 ± 0.2^b
CCl4 + SMSE (400 mg/kg)	46 ± 16^b	158 ± 13.56^b	171.5 ± 14.7^b	1.25 ± 0.5^b

Data are mean ± SD of five animals.
^aSignificantly different from control group .
^bSignificantly different from the CCl₄ group .