Red Sea Suberea mollis Sponge Extract Protects against CCl₄-Induced Acute Liver Injury in Rats via an Antioxidant Mechanism

Table 2

Effect of Suberea mollis sponge extract (SMSE) and silymarin on liver GPx, SOD, and CAT measured in CCl₄-induced hepatotoxicity in rats.

Treatment regimen	GPx; (mU/g tissue)	SOD; (U/g tissue)	CAT; (U/g tissue)
Control	24.8 ± 6.9	18.3 ± 4.8	8.2 ± 0.2
CCl4	5.3 ± 9.2^a	11.13 ± 3.6^a	4.8 ± 1.3^a
CCl4 + silymarin (100 mg/kg)	15.5 ± 4.7^b	17.8 ± 2.3^b	8.3 ± 0.3^b
CCl4 + SMSE (100 mg/kg)	29.1 ± 10.1^b	12.7 ± 2.8	4.5 ± 1.3
CCl4 + SMSE (200 mg/kg)	32.5 ± 13.6^b	16.8 ± 3.6	7.65 ± 0.5^b
CCl4 + SMSE (400 mg/kg)	42.3 ± 9.9^b	32.7 ± 6.5^b	7.9 ± 0.7^b

Data are mean ± SD of five animals.
^aSignificantly different from control group .
^bSignificantly different from the CCl₄ group .