Anti-Inflammatory and Antihyperalgesic Activities of Ethanolic Extract and Fruticulin A from Salvia lachnostachys Leaves in Mice

Figure 6

Effect of oral administration of SLEE or fruticulin A at paw withdraw threshold, on Von Frey test in mice. Animals received SLEE (300 mg/kg) or fruticulin A (3 mg/kg) or vehicle and after one hour 300 μg of carrageenan injection in the right hind paw. Mechanical hyperalgesia was measured at the times 3 and 4 hours after carrageenan injection using the digital analgesymeter. The bars express the mean ± SEM of 6 animals. The symbol compared vehicle (V) versus SLEE or fruticulin A treated groups and compared the control group before (basal) and after carrageenan treatment. ; ; ;  . Differences between groups were analyzed by analysis of variance (one-way ANOVA) followed by the Newman-Keuls test.