Anti-Inflammatory and Antihyperalgesic Activities of Ethanolic Extract and Fruticulin A from Salvia lachnostachys Leaves in Mice

Figure 8

Effect of local administration of fruticulin A at paw withdraw threshold, on mechanical allodynia induced by TNF or L-DOPA in mice. Animals received fruticulin A (1 μ/paw) or vehicle and after 15 minutes 1 pg/paw of TNF or L-DOPA injection in the right hind paw. Mechanical hyperalgesia was measured at the times 3 hours after TNF or L-DOPA injection using the digital analgesymeter. The bars express the mean ± SEM of 6 animals. The symbol compared vehicle (V) versus fruticulin A treated groups and compared the control group before (basal) and after TNF or L-DOPA treatment. , , difference in comparison with basal threshold levels or the vehicle-treated group. Differences between groups were analyzed by analysis of variance (one-way ANOVA) followed by the Newman-Keuls test.