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Evidence-Based Complementary and Alternative Medicine
Volume 2014 (2014), Article ID 843036, 11 pages
http://dx.doi.org/10.1155/2014/843036
Research Article

Determination of Efficacy of Reflexology in Managing Patients with Diabetic Neuropathy: A Randomized Controlled Clinical Trial

1Department of Biophysics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, India
2Department of Biostatistics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, India
3Department of Neurology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, India

Received 3 June 2013; Revised 22 September 2013; Accepted 20 November 2013; Published 9 January 2014

Academic Editor: David Baxter

Copyright © 2014 Krishna Dalal et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. The restricted usage of existing pharmacological methods which do not seem to provide the treatment of diabetic neuropathy may lead to exploring the efficacy of a complementary therapy. In this context, this paper was devoted to evaluate the efficacy of foot reflexology. This health science works on the hypothesis that the dysfunctional states of body parts could be identified by observing certain skin features and be rectified by stimulating certain specific areas mapped on feet. Method. Subjects () with diagnosed diabetic neuropathy were randomly distributed into reflexology and control groups in which both group patients were treated with ongoing pharmacological drugs. Reflexology group patients were additionally treated holistically with the hypothesis that this therapy would bring homeostasis among body organ functions. This was a caregiver-based study with a follow-up period of 6 months. The outcome measures were pain reduction, glycemic control, nerve conductivity, and thermal and vibration sensitivities. The skin features leading to the detection of the abnormal functional states of body parts were also recorded and analyzed. Results. Reflexology group showed more improvements in all outcome measures than those of control subjects with statistical significance. Conclusion. This study exhibited the efficient utility of reflexology therapy integrated with conventional medicines in managing diabetic neuropathy.

1. Introduction

Diabetes is the single most important metabolic disease, which can affect nearly every organ system in the body [1]. The prevalence of diabetes for all age groups worldwide was estimated to be 2.8% in 2000 and was expected to be raised up to 4.4% in 2030. The most important demographic change to diabetes prevalence across the world appears to be increased in the proportion of people older than 65 years of age [2]. According to the Diabetes Atlas 2006 published by the International Diabetes Federation, the number of people with diabetes in India is currently around 40.9 million and is expected to be raised to 69.9 million by 2025 unless urgent preventive steps are taken [3]. Much more alarming is the growing incidences of gestational diabetes in India, of which 60 percent of the population is known to develop diabetes later in life. These statistics are of great public health concern, because people with diabetes are 25 times more likely to develop blindness, 17 times more likely to develop kidney disease, 30 to 40 times more likely to undergo amputation, two to four times more likely to develop myocardial infarction, and twice as likely to suffer from a stroke than nondiabetics [4]. The common complication of diabetic mellitus is diabetic neuropathy. The pain can be severe and effectively destroy the quality of one’s life [5]. Development in the different types of neuropathy is correlated with the duration of diabetes and glycemic control. The commonest form of diabetic neuropathy is distal symmetric polyneuropathy in which the patients present with distal sensory loss, loss of ankle reflex, and abnormal position sense. The other features are hyperesthesia, paresthesia, and related pain [6]. Neuropathic pain occurs typically in the lower limb, usually presents at rest and worsens at night. With the progressive neuropathy, the associated pain subsides and eventually disappears and a sensory deficit in the lower extremities persists. The management of such a case is to improve (i) glycemic control, (ii) nerve conduction velocity, and (iii) vibrational and thermal sensitivities. However, with the use of conventional therapy, managing diabetic neuropathy is less than satisfactory [7]. Since the metabolic disorder can affect almost all the organ systems, in order to deal with such a situation, much attention should be paid to rectify the functioning of all the organ systems holistically together with stress management [8]. By adopting this procedure, one can only reverse the symptoms of neuropathy. And to realize this hypothesis for achieving maximum benefits, there has been considerable interest in integrating conventional therapies with “complementary and alternative medicine” (CAM) among the population in a larger part of the globe.

Reflexology therapy has emerged as a form of noninvasive and nonpharmacological complementary therapy for several medical conditions [9, 10]. Reflexology is the science of studying the human health through certain specific reflex/reflexology areas (RAs) quantized on feet, hands, and ears. It is reported in the literature that the application of reflexology therapy may rectify the organ dysfunction and establish homeostasis in the organ function [11, 12]. With its known beneficial effects on the improvement of the quality of life in cancer patients [13], reduction in pain and anxiety for patients with breast and lung cancer [14] and premenstrual syndrome [15, 16], reduction in seizure frequency, and improvement of the quality of life in intractable epilepsy [17], this clinical trial was launched to determine the efficacy of reflexology in the patients suffering from diabetic neuropathy. The hypothesis of reflexology is that the skin areas of feet/hands/ears are the representative of the target body parts and impulses generated on the reflexology areas by the external stimulations of definite intensities arrive at the target body parts through the neural pathways or through hormone-like activities [18]. These impulses are supposed to rectify the corresponding abnormally functioning status of the referred ones, if there is any. The working principle of reflexology therapy may follow the same one as that reported in acupuncture techniques [19, 20]. Keeping this in view, the present trial was conducted based on the aforesaid hypothesis of reflexology that the stimulations generated by the finger movements on foot reflexology areas (RAs) would restore the homeostasis of the body organ functions and hence have therapeutic effect on diabetic neuropathy. In this context, it may be mentioned that the previous studies conducted by the presenting authors could reveal a few characteristic abnormal features of RAs corresponding to certain abnormally functioning body parts [21, 22].

2. Methods

The methodologies are detailed in the subsections to follow.

2.1. Settings and Location

The subjects were recruited from the outpatient Department of Neurology, All India Institute of Medical Sciences, New Delhi, India, and were referred to the Department of Biophysics of the same institute for applying reflexology therapy. The clinical trial was ethically approved by the institutional ethics review board.

2.2. Sample Size Calculation

The sample size of this study was calculated considering reduction in neuropathic pain (measured by using visual analogue scale (VAS) score) as the primary outcome variable. With anticipated mean SD of VAS score in control group as 3.4 ± 0.5 [23] and expecting 40% more improvement in reflexology group, the sample size was calculated to be 36 samples per group with 95% confidence level and 90% power.

2.3. Subjects Screening and Randomization

A number of 109 subjects were screened to meet with the eligibility criteria of the clinical trial and a sample size of 71 subjects, diagnosed diabetic neuropathy, was selected for recruitment in the trial. A group of 13 patients were excluded from the trial due to their refusal to apply reflexology therapy by their own caregivers and being nonresidents of Delhi territory. Thus the trial ended up with 58 subjects who were allocated blindly to either reflexology group (reflexology therapy + conventional therapy) or to control group (conventional therapy alone) by computer generated random number in block randomization with 4 candidates per block. This procedure of randomization led to the recruitment of 29 subjects in reflexology group and 29 patients in control group, respectively. The details of the study subjects’ recruitment procedure are presented in a consort flow diagram as shown in Figure 1.

843036.fig.001
Figure 1: Consort diagram for subjects’ recruitment and followup.
2.4. Eligibility Criteria for Participants

Patients, with documented peripheral diabetic neuropathy whose glycosylated haemoglobin >6.5% and plasma glucose level ≥120 mg/decilitre (fasting) and ≥200 mg/deciliter (postprandial) for more than 1 occasion of any age of both genders, were included in the study. Subjects with end organ damage (namely, gangrene, or toes or foot amputation) due to diabetes mellitus/any cause, chronic disorders like malignancy, tuberculosis, asthma, or any communicable disease were excluded from the study.

2.5. Instructions for Both Group Patients

All the subjects were made to understand the importance of their active participations in this study by explaining the known effects and the hypothesis of reflexology therapy. The written instruction sheets, elaborating the therapy procedure as well as the protocol to be followed for their participations in the trial, were distributed to all the participants. It was thus assumed that there would be uniformity in the compliance of both group subjects.

2.6. Subjects’ Preparation prior to Optical Data Collection

The hypothesis that the functional status of an organ may be detected by observing certain features on the feet was explained to the subjects prior to their participations for recording the externally visible data on the feet. The instructions for maintaining a specific protocol of the pre-data-acquisition procedure were followed for maintaining the identical conditions of feet. The subjects’ feet were cleaned by wet cloth and allowed to air-dry while resting for 15 minutes. This procedure enabled one not only to make the feet optically clean but also to establish a uniform blood circulation in the feet. The whole procedure was conducted at an average room temperature of 25°C.

2.7. Physical Assessment of the RAs

All the reflexology areas were carefully observed and compared if there were the following abnormal signatures: (i) tenderness under a defined finger pressure as assessed by a pedography system (Emed-AT/2, Novel GmbH, Germany) in the range 30 N/cm2 to 35 N/cm2, (ii) a definite change in the related skin colour (namely, reddish brown/brown/dark brown/black), (iii) swelling (convex formation), (iv) hollowness (concave formation), (v) the feeling of depression with a finger pressure of a well defined strength, and (vi) the feeling of the presence of tiny granules with blurred finger nail scratching. The presence of any or a combination of these features on a RA led to conclude the area to be “abnormal” and hence the referred organ was declared to be abnormal [22]. The localized tenderness on a RA in response to the defined finger pressure was measured with the help of a VAS score with the scale range of “0” to “10.”

2.8. Optical and Swept Source-Optical Coherence Tomography (SS-OCT) Image Data Recordings

The skin images of the RAs were recorded, during the pretherapy sessions under the normalized condition as described, using an optical camera (Nikon D200, Japan). The SS-OCT with dermatology applications (OCM1300SS, Thorlabs Incorporated, Newton, New Jersey), comprising a high-speed frequency-swept external cavity laser ( nm), 3-dB spectral bandwidth (>100 nm), and an average output power of 10 mW, was used to record the subcutaneous data related to urinary bladder RAs at the pretherapy session. The instrument used for this purpose was described in detail in previous publications [21, 24].

2.9. Study Design for Reflexology Group Patients

A foot reflexology therapy application protocol was developed to treat the patients holistically. A step-by-step procedure was followed uniformly to stimulate the following RAs: energy balance [25], lymphatic system, solar plexus [26], adrenal glands, spine, urinary system, digestive system, brain, other endocrine glands, sciatic nerve, knee and hip. The hypothesis of this protocol was that stimulations on these specific areas would establish homeostasis in the functional status of the lymphatic, urinary, digestive and immunity systems together with releasing the mental stress, improving the diabetic control [27] and increasing the lower limb activities. The maps of the reflexology areas for these target body parts located on the feet had been followed as per the standard descriptions of various publications [2830], Indian school of reflexology practice [31], and in-house data records.

The patients were asked to visit the reflexology laboratory once in a week during the first month of the trial as this was the period for generating trained caregivers. During this period, the performances of the caregivers in applying therapy to their patients were checked every week. The patients' responses to a particular therapy step were recorded to note the effect of stimulations on the corresponding reflexology areas of the referring system.

Stimulations in the form of mechanical pressure and relaxation on a particular RA were uniformly produced by fingers using both the hands of the caregivers. The fingers of one hand were used for producing stimulations and the other one for holding the foot firmly against the application of pressure. Moderate pressure, in the range of 30 N/cm2 to 35 N/cm2 as recorded using pedography system, Emed-AT/2, Novel GmbH (Germany) [32], with tolerable tenderness was used to generate stimulations. The areas were lubricated with cream of milk without any additive before applying stimulation in order to avoid any adverse effect on the skin due to friction. Each reflexology area was stimulated (average) 15 times of ~20 seconds duration per session with the understanding that stimulations on a particular RA < 10 times did not produce any therapeutical effect and a RA would be overstimulated with continuous stimulations >20 times. One therapy session took ~1/2 hour duration and there were 2 therapy sessions per day.

2.10. Conventional Therapy for Both Groups

The institute standard mode of pharmacological management for treating neuropathy with diabetic mellitus was followed for both groups during the trial period.

2.11. Evaluation of Treatment Compliance for Both Groups during Follow-Up Period

For the purpose of followup, the subjects were present at the reflexology laboratory (for reflexology group) and neuropathy clinic (both groups) once in a month for the remaining five months (initial one month was the training period for reflexology group patients). The quality assurance of the compliance of both group patients was monitored critically by pill counting method [33] (both groups) and by the reflexology method [21, 22] (reflexology group) as well as by noticing the individual performances of the caregivers while applying the therapy. An identical method of health monitoring program for both the groups was followed and it was independently done by the clinicians physically located separately from the reflexology laboratory. The follow-up period was 6 months including the training period (reflexology group). There was an option to the participating subjects for withdrawing themselves from the trial at their own desire. However, the trial did not encounter any such situation.

2.12. Outcome Measures

The primary outcome measure was neuropathic pain using VAS score and the secondary outcome measures were the levels of HbA1c and blood glucose (fasting and postprandial), thermal and vibration sensitivity, nerve conduction velocity (NCV), and quality of life. The quality of life was evaluated with the help of “neuroQoL” instrumentation [34] to assess the following: (1) symptomatic affliction, (2) psychosocial impairment, (3) diabetic neuropathy-specific impact, and (4) overall quality of life. The mode of measuring the quality of life using NeuroQoL was that the lower was the score, the better was the quality of life [35]. Thermal and vibration sensitivities were measured by using Vibrotherm analyzer (Vibrotherm Dx, Diabetik Foot care, India) [35, 36]. As per the data supplied by the manufacturer, the thermal (both hot and cold) perception threshold was measured in the temperature range of 1°C to 50°C with the rate of temperature change of 1°C per second. These were recorded by keeping a constant contact of a hand held probe tip of diameter 20 mm to the specific areas on the feet. The test was performed at an average room temperature of 25°C. The perception of the probe temperature more than 32°C was considered to be “abnormal” hot sensation and that less than 23°C was taken as “abnormal” cold sensation. The vibration perception threshold was assessed using the vibration probe tip of 15 mm diameter and vibration frequency of 100 Hz in the amplitude range of 0–50 volts. The specified normal threshold vibration amplitude was ≤15 volts.

Peripheral nerve conduction studies were performed using Viking Quest, Nicolet Viasys Healthcare, (Nicolet Biomedical, USA) [3739]. Both motor and sensory nerves were examined using the standard settings and filters as specified by the manufacturer. The appropriate anatomical sites were stimulated using a surface electrical stimulator. The normative data of the parameters were used from the study institute reference values.

2.13. Data Analyses

Data were presented as number (%) or mean ± SD or median (range) as appropriate. In this trial, age and neuropathic pain score (VAS) was found to be normally distributed. Baseline characteristics were summarized between the groups. The median (range) for % improvements in neuropathy (VAS score) in the two-groups and the difference in % improvements were compared using two group Wilcoxon rank sum test (nonparametric test). Difference in means between the groups was compared using Student’s -test for independent samples. The change in posttherapy values from baseline was tested for continuous variables using paired -test and categorical variables using Mc Nemar’s statistical analysis. The differences in proportions between the groups were tested using Chi square test/Fisher’s exact test. The value less than 0.05 was considered statistically significant. Statistical analysis was carried out using STATA 9.0 (College station, Texas, USA).

The % improvement in neuropathy of an individual subject within a group was calculated in terms of % reduction in pain and was defined according to (1) as follows:

VASpre-th and VASpost-th are the pain scores at the baseline and at the end of follow-up period, respectively. The positive or negative sign of (1) indicates reduction or enhancement in neuropathic pain at the posttherapy session with respect to the baseline one.

Similarly, the % improvement within a group in either of the specified parameters like HbA1c and Blood glucose (fasting and post prandial) in which the levels are supposed to be reduced with therapy, if the same would have positive response, was also determined using the following equation, similar to (1):

Parameterpre-th and Parameterpost-th represent the mean value of either of the following: HbA1c or fasting blood glucose and postprandial blood glucose, at the pretherapy session and posttherapy session, respectively, within a specified group.

3. Results

The results of this clinical trial are detailed in the subsections to follow.

3.1. Demographics

All the data are presented in terms of (mean ± SD) or median (range) in this section. The age (mean ± SD), gender ratio (male : female), the duration of diabetes mellitus [median (range)] and the duration of neuropathy [median (range)], for reflexology group () were years; 16 : 13; 10 (3–28) years; 5 (1–14) years, respectively. The respective values for control group () were ; 15 : 14; 13 (4–30); 6 (2–8). All the baseline data were statistically comparable between two groups, except the abnormal perception of cold and vibration sensitivities.

3.2. Observations on Primary Outcome Measure

The baseline VAS score, describing pain intensity, was reduced from to at the end of follow-up period with highly statistical significance ( value ) for reflexology group patients. Control group subjects exhibited VAS score reduction from baseline to at the end of follow-up period. The median [range] improvement in reflexology group was 66.6% [14.2%–90.0%] and that in control group was 14.2% [(−25%)–87.5%]. That is, difference in neuropathic pain reduction in reflexology group with respect to that of control group patients was found to be 52.4% with a value .

3.3. Observations on Secondary Outcome Measures

The data on secondary outcome measures are tabulated in Tables 1 and 2 which exhibit that there was positive response in each category of the parameters with statistical significance () among reflexology group patients. The maximum response was obtained in improving cold sensitivity with 100% response among reflexology group subjects. Each of the responses was found to be statistically significant except postprandial blood glucose frequency ().

tab1
Table 1: Comparison of pre- and posttherapy glycosylated hemoglobin and blood glucose in between the groups.
tab2
Table 2: Comparison of different parameters between groups.

The quality of life in patients with diabetic neuropathy, measured by NeuroQoL instrument, revealed that the baseline score was reduced from 8 (4–10) to 4 (1–6) at the end of follow-up period in reflexology group, whereas in control group it was reduced from 7 (4–9) to 5 (3–8). This result reveals that there was 21.3% more improvement in reflexology group than that of control one with value and 95% confidence interval.

3.4. Observation on Reflexology Areas

The abnormal physical characteristics like tenderness, hyperpigmentation, convexity (swelling), concavity (hollowness formation), change in skin colour, and the feeling of the presence of tiny granules in RAs were noted among reflexology group patients. A few examples on abnormal RAs are shown in Figure 2. These externally observed features of different RAs got improved with statistical significance ( value ) at the end of the follow-up period (Table 3). Figure 3 exhibits 2 examples of abnormal skin colour at the baseline and the respective status at the end of follow-up period. Abnormal reddish brown skin colour of pancreas and that of adrenal gland RAs disappeared with reflexology therapy and these RAs exhibited normal skin colour at the end of the follow-up period. Figure 4 depicts the subcutaneous (up to 1.75 mm) features of the urinary bladder RAs. It describes the subcutaneous layer characteristics related to “normal” and different categories of “abnormal” RAs.

tab3
Table 3: Comparison of the status of reflexology areas** at baseline and at end of follow-up period (reflexology group: ).
843036.fig.002
Figure 2: Abnormal skin features of the reflexology areas (RAs) of urinary bladder (UB), solar plexus, pituitary gland, pancreas, lumbar vertebrae, and sciatic nerve. (a)–(c) convex UB RAs; (a) 66M; (b) 73M; (c) 53F convex and reddish UB RA; (d) 65F: reddish brown and concave solar plexus RAs; (e) 56F: dark brown and concave solar plexus RAs (e1) and dark brown pituitary gland RAs (e2); (f) 58M: reddish brown pancreas RA (f1) and reddish brown lumbar vertebrae RA (f2); (g1)-(g2) 30F: concave and brown sciatic nerve RAs.
fig3
Figure 3: Observations on pancreas (63M) and adrenal gland (58M) reflexology areas at the pre- and post-reflexology therapy sessions. (a) pretherapy session: reddish brown skin colour of pancreas RA; (b) posttherapy session: pancreas RA with normal skin colour; (c) pretherapy session: reddish brown adrenal gland RA and (d) posttherapy session: adrenal gland RA with normal skin colour.
fig4
Figure 4: A few examples of the subcutaneous features (up to 1.75 mm) of urinary bladder reflexology areas. (a) A normal structure (without the presence of any abnormal skin characteristics); (b) the onset of an abnormal condition (tender RA); (c) an abnormal condition (tender and swollen RA); (d) an advanced stage of abnormality (tender, swollen and hard skin).

4. Discussion

This was an open label clinical trial based on the assumption that reflexology therapy intervention would achieve 40% improvement from the result with ongoing pharmacological drugs and accordingly the required sample size was estimated. Improvement in the primary outcome measure, that is, on the reduction of neuropathic pain, in reflexology group at the end of follow-up period with respect to the baseline was observed to be 52.4% more than control group. As the difference in primary outcome variable was statistically significant ( value ) and more than the anticipated one, this study ending with 29 subjects per group had adequate power to detect the observed difference.

All the subjects were admitted into the trial as per the selection criteria and were randomized blindly irrespective of age, gender, socioeconomic status, and duration of neuropathy. Much attention was paid amongst reflexology group patients for maintaining the quality and uniformity of standardized therapy compliance. However, there could be some variations in reflexology intervention received by the patients through their caregivers performing therapy at their preferable places. This was the main limitation of the trial with reflexology group patients in applying reflexology therapy lacking in quantification because of its manual and subjective nature. The corresponding error was minimized by monitoring the performances of the caregivers on a regular time interval and the quality assurance of therapy compliance was monitored by noting the status of the reflexology areas in terms of tenderness, concavity/convexity, pigmentation, and feeling the presence of foreign tiny particles as demonstrated in Figures 2 and 3.

On completion of the trial, the clinical status of all the study subjects was compared between 2 groups. It was observed that reflexology group patients responded with highly statistical significance. These patients were applied therapy holistically and accordingly, the uniform therapy application protocol was designed and followed. An objective method of monitoring the quality assurance of reflexology therapy compliance was adopted. This method was involved in observing the externally visible abnormal features [21, 24] of the reflexology areas as mentioned. With improvements in different parameters presented in Tables 1 and 2, the abnormal features of the respective RAs also disappeared as supported by the data stated in Table 3. This procedure of evaluating the reflexology areas may offer a method of testing the hypothesis of the reflexology principle that stimulations at the reflexology areas may repair the respective abnormal status and hence rectify the corresponding organ function.

In 2 cases of reflexology group there was no abnormal feature observed on the specified RAs though these subjects were diagnosed with confirmed diabetic neuropathy. At the initial stage of therapy session these patients did not complain of tenderness against moderate finger pressure stimulations applied to any RA in contrast to other 27 reflexology subjects. Later on (after a week) tenderness was felt against the specified finger pressure stimulations and they were treated by the method as followed in other cases. The control group subjects did not take part in the reflexology method of detecting the functional status of the organs and hence the respective characteristics of the RAs were not evaluated.

It may be recalled that all the reflexology group subjects were suffering for 10 years median duration of uncontrolled diabetic mellitus and 5 years median duration of neuropathy and were on the ongoing conventional medicines. In this respect, the holistic application of reflexology therapy in conjunction with the pharmacological drugs improved the blood glucose levels and glycemic control with highly statistical significances. And in its own turn, it would perhaps also pave the way to have remedy to neuropathic pain together with improvement in nerve conduction velocity and thermal and vibration sensitivities as well as in the quality of life. However, though this study indicates the high efficacy of reflexology therapy as an adjunctive therapy to conventional medicines in managing diabetic neuropathy and its complicacy, it is to remember that its application is very much restricted because of its subjective nature.

5. Conclusions

This study demonstrated that reflexology therapy in addition to pharmacological therapy may be recommended in reducing the neuropathic pain and improving quality of life and may achieve holistic benefits to the patients suffering from diabetic neuropathy. However, the evaluation of reflexology therapy as an adjunctive regimen warrants further investigations to be carried out in a larger sample size amongst various communities.

Conflict of Interests

The authors declare no conflict of interests.

Acknowledgments

This work had been carried out with financial support of Indian Council of Medical Research, Government of India. The authors thankfully acknowledge the experimental facilities extended by Jyotirmoy Chatterjee Ph.D., Associate Professor, Indian Institute of Technology, Kharagpur, India, for collecting data on SS-OCT images. One of the authors V. Bharathi Maran thankfully acknowledges the assistance of Elanchezhiyan D. for data collection.

References

  1. R. Pradeepa, R. Deepa, and V. Mohan, “Epidemiology of diabetes in India—current perspective and future projections,” Journal of the Indian Medical Association, vol. 100, no. 3, pp. 144–148, 2002. View at Scopus
  2. S. Wild, G. Roglic, A. Green, R. Sicree, and H. King, “Global Prevalence of Diabetes: estimates for the year 2000 and projections for 2030,” Diabetes Care, vol. 27, no. 5, pp. 1047–1053, 2004. View at Publisher · View at Google Scholar · View at Scopus
  3. V. Mohan, S. Sandeep, R. Deepa, B. Shah, and C. Varghese, “Epidemiology of type 2 diabetes: Indian scenario,” Indian Journal of Medical Research, vol. 125, no. 3, pp. 217–230, 2007. View at Scopus
  4. B. M. Kutty and T. R. Raju, “New vistas in treating diabetes—insight into a holistic approach,” Indian Journal of Medical Research, vol. 131, no. 5, pp. 606–607, 2010. View at Scopus
  5. B. E. Sumpio, T. Lee, and P. A. Blume, “Vascular evaluation and arterial reconstruction of the diabetic foot,” Clinics in Podiatric Medicine and Surgery, vol. 20, no. 4, pp. 689–708, 2003. View at Publisher · View at Google Scholar · View at Scopus
  6. A. D. Timmis, “Diabetes,” British Medical Bulletin, vol. 59, pp. 159–172, 2001.
  7. A. I. Vinik, “Management of neuropathy and foot problems in diabetic patients,” Clinical Cornerstone, vol. 5, no. 2, pp. 38–52, 2003. View at Publisher · View at Google Scholar · View at Scopus
  8. D. I. Galper, A. G. Taylor, and D. J. Cox, “Current status of mind-body interventions for vascular complications of diabetes,” Family & Community Health, vol. 26, no. 1, pp. 34–40, 2003. View at Scopus
  9. J. Bliss and G. Bliss, “Theories on how reflexology works,” Reflections Assoc Reflexol J, 1999.
  10. C. M. Hughes, S. Krirsnakriengkrai, S. Kumar, and S. M. McDonough, “The effect of reflexology on the autonomic nervous system in healthy adults: a feasibility study,” Alternative Therapies in Health and Medicine, vol. 17, no. 3, pp. 32–37, 2011. View at Scopus
  11. K. Kunz and B. Kunz, The Complete Guide to Foot Reflexology (Revised), Reflexology Research Project, D, Albuquerque, NM, USA, 1993.
  12. V. Pitman and K. Mackenzie, Reflexology—A Practical Approach, Nelson Thornes, Cheltenham, UK, 2002.
  13. H. Hodgson, “Does reflexology impact on cancer patients' quality of life?” Nursing Standard, vol. 14, no. 31, pp. 33–38, 2000. View at Scopus
  14. N. L. Stephenson, S. P. Weinrich, and A. S. Tavakoli, “The effects of foot reflexology on anxiety and pain in patients with breast and lung cancer,” Oncology Nursing Forum, vol. 27, no. 1, pp. 67–72, 2000. View at Scopus
  15. M. Valiani, E. Babaei, R. Hesmat, and Z. Zare, “Comparing the effects of reflexology methods and Ibuprofen administration on dysmenorrhea in female students of Isfahan University of Medical Sciences,” Iranian Journal of Nursing and Midwifery Research, vol. 15, supplement 1, pp. 371–378, 2010.
  16. Y. H. Kim and S. H. Cho, “The effect of foot reflexology on premenstrual syndrome and dysmenorrhea in female college students,” Korean Journal of Women Health Nursing, vol. 8, pp. 212–221, 2002.
  17. K. Dalal, E. Devarajan, R. M. Pandey, V. Subbiah, and M. Tripathi, “Role of reflexology and antiepileptic drugs in managing intractable epilepsy—a randomized controlled trial,” Forsch Komplementmed, vol. 20, no. 2, pp. 104–111, 2013. View at Publisher · View at Google Scholar
  18. D. Tiran and H. Chummun, “The physiological basis of reflexology and its use as a potential diagnostic tool,” Complementary Therapies in Clinical Practice, vol. 11, no. 1, pp. 58–64, 2005. View at Publisher · View at Google Scholar · View at Scopus
  19. M. Shwartz, R. Saitz, K. Mulvey, and P. Brannigan, “The value of acupuncture detoxification programs in a substance abuse treatment system,” Journal of Substance Abuse Treatment, vol. 17, no. 4, pp. 305–312, 1999. View at Publisher · View at Google Scholar · View at Scopus
  20. D. Li, Y. Benlin, Wang, and Zhaorong, Acupuncture Meridian Therapy and Acupuncture Points, Foreign language Press, Beijing, China, 1991.
  21. K. Dalal, D. Elanchezhiyan, V. B. Maran, et al., “Optical, spectroscopic, and Doppler evaluation of “Normal” and “Abnormal” reflexology areas in lumbar vertebral pathology: a case study,” Case Reports in Medicine, vol. 2012, Article ID 904729, 9 pages, 2012. View at Publisher · View at Google Scholar
  22. K. Dalal, D. Elanchezhiyan, R. Das, et al., “Noninvasive characterisation of foot reflexology areas by swept source-optical coherence tomography in patients with low back pain,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, Article ID 983769, 11 pages, 2013. View at Publisher · View at Google Scholar
  23. A. Beydoun, S. A. Kobetz, and E. J. Carrazana, “Efficacy of oxcarbazepine in the treatment of painful diabetic neuropathy,” Clinical Journal of Pain, vol. 20, no. 3, pp. 174–178, 2004. View at Publisher · View at Google Scholar · View at Scopus
  24. A. Barui, P. Banerjee, R. Patra et al., “Swept-source optical coherence tomography of lower limb wound healing with histopathological correlation,” Journal of Biomedical Optics, vol. 16, no. 2, Article ID 026010, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. W. H. Fitzerald and E. F. Bowers, Hand Book of Zone Therapy (Cures for Common Ailments), D.B. Taraporevala Sons, Mumbai, India, 1986.
  26. D. Q. Theron, The Solar Plexus or Abdominal Brain, Cosimo Inc, New York, NY, USA, 2010.
  27. A. J. McVicar, C. R. Greenwood, F. Fewell, V. D'Arcy, S. Chandrasekharan, and L. C. Alldridge, “Evaluation of anxiety, salivary cortisol and melatonin secretion following reflexology treatment: a pilot study in healthy individuals,” Complementary Therapies in Clinical Practice, vol. 13, no. 3, pp. 137–145, 2007. View at Publisher · View at Google Scholar · View at Scopus
  28. H. Marquardt, Reflex Zone Therapy of the Feet, a Text for Therapists, Thorsons Publishers, Northamptonshire, UK, 1983.
  29. I. Dougans, Complete Illustrated Guide to Reflexology, Barnes & Noble Books, New York, NY, USA, 1996.
  30. D. C. Byers, The Original Works of Eunice D Ingham, Ingham Publishing, Saint Petersburg, Fla, USA, 1992.
  31. I. P. Bahl, Listen to Your Feet, Hind Pocket Books, New Delhi, India, 2005.
  32. N. Taisa Filippin, T. de Almeida Bacarin, and P. H. Lobo da Costa, “Comparison of static footprints and pedobarography in obese and non-obese children,” Foot and Ankle International, vol. 29, no. 11, pp. 1141–1144, 2008. View at Publisher · View at Google Scholar · View at Scopus
  33. P. Barnestein-Fonseca, J. Leiva-Fernández, F. Vidal-España, A. García-Ruiz, D. Prados-Torres, and F. Leiva-Fernández, “Is it possible to diagnose the therapeutic adherence of patients with COPD in clinical practice? A cohort study,” BMC Pulmonary Medicine, vol. 11, article 6, 2011. View at Publisher · View at Google Scholar · View at Scopus
  34. L. Vileikyte, M. Peyrot, C. Bundy et al., “The development and validation of a neuropathy- and foot ulcer-specific quality of life instrument,” Diabetes Care, vol. 26, no. 9, pp. 2549–2555, 2003. View at Publisher · View at Google Scholar · View at Scopus
  35. N. C. Kwai, R. Arnold, C. Wickremaarachchi, et al., “Effects of axonal Ion-channel dysfunction on quality of life in type 2 diabetes,” Diabetes Care, vol. 36, no. 5, pp. 1272–1277, 2013. View at Publisher · View at Google Scholar
  36. P. Jayaprakash, A. Bhansali, S. Bhansali et al., “Validation of bedside methods in evaluation of diabetic peripheral neuropathy,” Indian Journal of Medical Research, Supplement, vol. 133, no. 6, pp. 645–649, 2011. View at Scopus
  37. K. Patel, M. Patel, and S. N. Gupta, “Effect of Atibalamula and Bhumyamalaki on thirty-three patients of diabetic neuropathy,” Ayu, vol. 32, no. 3, pp. 353–356, 2011.
  38. J.-W. G. Meijer, A. J. Smit, J. D. Lefrandt, J. H. Van Der Hoeven, K. Hoogenberg, and T. P. Links, “Back to basics in diagnosing diabetic polyneuropathy with the tuning fork!,” Diabetes Care, vol. 28, no. 9, pp. 2201–2205, 2005. View at Publisher · View at Google Scholar · View at Scopus
  39. S. J. Bird, M. J. Brown, C. Spino, S. Watling, and H. L. Foyt, “Value of repeated measures of nerve conduction and quantitative sensory testing in a diabetic neuropathy trial,” Muscle and Nerve, vol. 34, no. 2, pp. 214–224, 2006. View at Publisher · View at Google Scholar · View at Scopus
  40. R. Mahony, C. O'Brien, B. Kinsley et al., “Antepartum pudendal neuropathy and the effect of vaginal delivery in women with type 1 diabetes mellitus in pregnancy,” International Journal of Diabetes & Metabolism, vol. 14, no. 2, pp. 82–86, 2006. View at Scopus