Evidence-Based Complementary and Alternative Medicine / 2014 / Article / Tab 4 / Review Article
Recent Advances in Developing Insect Natural Products as Potential Modern Day Medicines Table 4 Examples of recent studies on the use of cantharidin.
Cells treated Results References (1) Human colorectal cancer cells Reduced CDK1 kinase activity, apoptosis induction through mitochondrial and death receptor pathways, and activation of caspases 8, 9, and 3 Huang et al. [85 ] (2) Human bladder carcinoma cells Blocked activities of matrix metalloproteinase-2 (MMP-2) and/or MMP-9 resulting in an antimetastatic effect Huang et al. [86 ] (3) Human breast cancer cells Reduced adhesion and migration by repressed cell adhesion to platelets by downregulation of
2 integrin adhesion molecule Shou et al. [87 ] (4) Yeast CRG1 (cantharidin resistance gene 1) Details of transcriptional regulation of the CRG1 gene for methyltransferase, during cantharidin stress Lissina et al. [79 ] (5) Hepatocellular carcinoma cells A new gene therapy approach to kill hepatocellular carcinoma cells by inhibiting PP2A with the α -fetoprotein promoter enhancer linked to the pgk promoter Li et al. [88 ] (6) Normal rats Design of cantharidin solid lipid nanoparticles as drug carriers which can be given orally Dang and Zhu [89 ]