Optimization of Phenolics Extracted from Idesia polycarpa Defatted Fruit Residue and Its Antioxidant and Depigmenting Activity In Vitro and In Vivo

Table 2

ANOVA for the effect of ethanol concentration, liquid to solid ratio, temperature, and time on the yield of phenolics using a quadratic response surface model.

Source	SS^a	df^b	MS^c	𝐹 ratio	𝑃 value
Model	4.15	14	0.30	27.40	<0.0001
𝑋1	0.067	1	0.067	6.24	0.0256
𝑋2	4.044𝐸−003	1	4.044𝐸−003	0.37	0.5506
𝑋3	0.15	1	0.15	13.44	0.0025
𝑋4	0.11	1	0.11	10.18	0.0065
𝑋1𝑋2	3.086𝐸−003	1	3.086𝐸−003	0.29	0.6016
𝑋1𝑋3	3.940𝐸−004	1	3.940𝐸−004	0.036	0.8513
𝑋1𝑋4	2.117𝐸−004	1	2.117𝐸−004	0.020	0.8907
𝑋2𝑋3	2.709𝐸−003	1	2.709𝐸−003	0.25	0.6245
𝑋2𝑋4	1.863𝐸−004	1	1.863𝐸−004	0.017	0.8974
𝑋3𝑋4	6.100𝐸−003	1	6.100𝐸−003	0.56	0.4650
𝑋1^2	0.12	1	0.12	11.18	0.0048
𝑋2^2	0.42	1	0.42	39.23	<0.0001
𝑋3^2	1.24	1	1.24	114.91	<0.0001
𝑋4^2	3.12	1	3.12	288.17	<0.0001
Residual	0.15	14	0.011
Lack of fit	0.12	10	0.012	1.57	0.3511
Pure error	0.031	4	7.668𝐸−003
𝑅^2	0.9648
Adj 𝑅^2	0.9296

aSum of squares, bmean square, and cdegree of freedom.