Optimization of Phenolics Extracted from Idesia polycarpa Defatted Fruit Residue and Its Antioxidant and Depigmenting Activity In Vitro and In Vivo

Table 4

Effects of EAE against mushroom tyrosinase and on cell growth of B16 cells.

Sample	Mushroom tyrosinase; IC50 (tyrosine, mg/mL)	Mushroom tyrosinase; IC50 (L-Dopa, mg/mL)	Cytotoxicities; LD50 (g/mL)^a
EAE	1.009±0.046	2.122±0.106	29.407±0.381
Hydroquinone	0.983±0.032	2.173±0.188	2.798±0.106
Arbutin	1.407±0.067^A	3.5994±0.193^A	—

aLD₅₀: 50% lethal dose.
^A𝑃<0.01 compared with EAE.