Fumanjian, a Classic Chinese Herbal Formula, Can Ameliorate the Impairment of Spatial Learning and Memory through Apoptotic Signaling Pathway in the Hippocampus of Rats with Aβ_1–40-Induced Alzheimer’s Disease

Figure 3

Representative photomicrographs of TUNEL staining in the hippocampus CA1 area of each group (×400). (A) 100 × hippocampus; (B) normal control group; (C) sham-operated group; (D) model group; (E) Fumanjian high dosage group; (F) Fumanjian mid-dosage group; (G) Fumanjian low dosage group; (H) Aricept positive control group. Quantitative analysis showed that treatment group reduced the number of TUNEL-positive cells in the hippocampus CA1 area. ^∗∗𝑃<0.01, compared with sham-operation group; ^△△𝑃<0.01, compared with NS+A𝛽 group; ^##𝑃<0.01, compared with NS+A𝛽 group. NS: normal saline; A𝛽: amyloid-𝛽; H-FMJ: Fumanjian high dosage group; M-FMJ: Fumanjian medium dosage group; L-FMJ: Fumanjian low dosage group.

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