Suxiao Jiuxin Pill Induces Potent Relaxation and Inhibition on Contraction in Human Artery and the Mechanism

Figure 1

Mean concentration- (log mg/mL for Suxiao Jiuxin Pill; −log𝑀 for GTN and amlodipine) relaxation curves for Suxiao Jiuxin Pill, GTN, and amlodipine in KCl- (25~40 mM, (a)) or U46619- (10~20 nM, (b)) induced contraction in human IMA (𝑛=8 in each group). % relaxation to KCl (or U46619): percentage relaxation induced by Suxiao or other vasodilators in the KCl- (or U46619-) induced precontraction. Ethanol was the solvent of Suxiao Jiuxin Pill. Values are expressed as mean ± SEM. ^∗𝑃<0.05, ^∗∗𝑃<0.01 compared to vehicle group (unpaired 𝑡-test). KCl: potassium chloride; GTN: glyceryl trinitrate; Suxiao: Suxiao Jiuxin Pill.

(a)

(b)