Updates on the Clinical Evidenced Herb-Warfarin Interactions

Table 1

Scoring of clinical severity of herb-warfarin interaction [14].

Clinical severity	Potentiation	Inhibition
Major	Death, major bleeding, entailing entire cease of warfarin therapy	Occurrence of thrombosis
Moderate	INR increase, entailing adjustment in warfarin dosage; INR increase to greater than 5.0; INR increase by greater than 1.5 units	INR decrease, entailing adjustment in warfarin dosage; INR decrease to less than 1.5; INR decrease by greater than 1.5 units
Minor	INR increase but requiring no change in warfarin dosage; INR increase to no more than 5.0; INR increase by smaller than 1.5 units	INR decrease but requiring no change in warfarin dosage; INR decrease to no more than 1.5; INR decrease by smaller than 1.5 units
Nonclinical	No change in INR	No change in INR