Research Article
Anti-Trichophyton Activity of Protocatechuates and Their Synergism with Fluconazole
Table 2
Activity of fluconazole combined with pentyl, hexyl, heptyl, octyl, and nonyl protocatechuates against T. rubrum and T. mentagrophytes (mg/L).
| | | MIC (mg/L) | FIC index (association type) | | | Substances alone | Substances combined | | | | FLU | 7 | 8 | 9 | 10 | 11 | FLU + 7 | FLU + 8 | FLU + 9 | FLU + 10 | FLU + 11 | FLU + 7 | FLU + 8 | FLU + 9 | FLU + 10 | FLU + 11 |
| | Tr1 | 2.0 | 7.8 | 3.9 | 1.9 | 1.9 | 1.9 |
0.12*—7.80 | 2.00—0.48* | 0.12*—1.9 | 2.00—0.06** | 2.00—0.03** | 1.0 (A) | 1.1 (I) | 1.0 (A) | 1.0 (A) | 1.0 (A) | | Tm1 | 1.0 | 3.9 | 1.9 | 3.9 | 1.9 | 3.9 | 1.00—0.03** | 1.00—0.03** | 1.00—0.03** | 1.00—0.03** | 1.00—0.03** | 1.0 (A) | 1.0 (A) | 1.0 (A) | 1.0 (A) | 1.0 (A) | | Tm3 | 0.5 | 7.8 | 3.9 | 3.9 | 3.9 | 3.9 | 0.50—0.03 | 0.12—1.9* | 0.12—0.97* | 0.12—1.9* | 0.50—0.03 | 1.0 (A) | 0.72 (A) | 0.48 (S) | 0.72 (A) | 1.0 (A) |
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MIC: minimal inhibitory concentration; FIC: fractional inhibitory concentration; S: synergistic effect; A: additive effect; I: indifferent effect Tr1: clinical strain of T. rubrum; Tm1: clinical strain of T. mentagrophytes; and Tm3: T. mentagrophytes ATCC 40131. *; **.
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