A Systematic Review for Anti-Inflammatory Property of Clusiaceae Family: A Preclinical Approach

Table 1

Description of the anti-inflammatory aspects of the studies included in systematic review.

References	Scientific name	Parts used	Animal	Dose	Route	Methods used	Action mechanism
Trovato et al., 2001 [11]	H. empetrifolium	APME	Wistar rats	100 mg/kg	i.p.	CIPE	Inhibition of PG
Ozturk et al., 2002 [12]	H. triquetrifolium	DAPE	Wistar rats	25–60 mg/kg	i.p.	CIPE	Without mechanism
Rabanal et al., 2005 [13]	H. canariense; H. glandulosum	BME	Swiss mice	0.25–1 mg/ear	t.a.	TPAIEE	Inhibition of AA metabolism
Abdel-Salam 2005 [14]	H. perforatum	Commercial extract	Sprague-Dawley rats	50–300 mg/kg	s.c.	CIPE	Inhibition of the liberation of HIS, 5-HT, KN
Sánchez-Mateo et al., 2006 [15]	H. reflexum	BME	Swiss mice	0.25–1 mg/ear	t.a.	TPAIEE	Inhibition of PLA2, COX, and LOX
Nguemfo et al., 2007 [16]	A. monticola	SBMCME	Wistar rats	75–300 mg/kg	p.o.	CIPE; HSIPE; AAIPE; DIPE	Inhibition of AA metabolism
Šavikin et al., 2007 [17]	H. perforatum; H. barbatum; H. hirsutum; H. richeri; H. androsaemum.	DAPE	Wistar rats	25–200 mg/kg	p.o.	CIPE	Inhibition of NF-𝜅B.
Frutuoso et al., 2007 [18]	R. longifolia	LAE	Swiss mice; Wistar rats	10–100 mg/kg	p.o.	PILPS	Inhibition of neutrophil
Ymele et al., 2013 [19]	A. gabonensis	SBAE	Wistar rats	100–400 mg/kg	p.o.	CIPE; HSIPE	Reduced liberation and action of His and 5-HT; inhibition AA metabolism
Šavikin et al., 2007 [17]	H. perforatum; H. barbatum; H. hirsutum; H. richeri; H. androsaemum.	DAPE	Wistar rats	25–200 mg/kg	p.o.	CIPE	Inhibition of NF-𝜅B.
Panthong et al., 2007 [20]	G. hanburyi	BEAE	Sprague-Dawley rats	10–40 mg/kg	p.o.	EPPIEE; CIPE; AAIPE; GGICP	Inhibition of the liberation of His, PG, KN
Castardo et al., 2008 [21]	G. gardneriana	LHE	Swiss mice	30–300 mg/kg	i.p.	CIPE; HSIPE; TPAIPE; BKIPE; AAIPE MPOAA; SPIPE	Inhibition of the activity of neuropeptides and PKC
Galati et al., 2008 [22]	H. rumeliacum	APME	Wistar rats	50; 70 mg/kg	i.p.	CIPE	Without mechanism
Martins et al., 2008 [23]	G. brasiliensis	FPO	Wistar rats	100 mg/kg	p.o.	CIPE	Without mechanism
dos Reis et al., 2009 [24]	G. cambogia	FPE	Wistar rats	0.5; 1.0 g/kg	p.o.	CITNBS; MPOAA; EMPGE2	Inhibition COX-2 expression and production of PGE2
Zdunić et al., 2009 [25]	H. perforatum	FTOE	Wistar rats	1.25 mL/Kg	p.o.	CIPE	Without mechanism
Paterniti et al., 2010 [26]	H. Perforatum	ME	Sprague-Dawley rats	2 mg/kg		PIL; MPOAA; MVP; CE	Reduces the NF-𝜅B translocation; inhibition the I𝜅B-𝛼 degradation; attenuation of the expression of iNOS
Süntar et al., 2010 [27]	H. perforatum	APOOE; APEE	Sprague-Dawley rats; Swiss mice	50–400 mg/kg	p.o.	AcAICP	Without mechanism
Otuki et al., 2011 [28]	G. gardneriana	LHE; BHE; SHE	Swiss Webster mice	0.01–1 mg/ear	t.a.	COIEE; MPOAA	Inflammatory signal transduction pathway not specified
Ozturk et al., 2011 [12]	G. brasiliensis	LEE	Wistar rats	30–300 mg/kg	p.o.	CIPE; PILPS; GGICP	Inhibition of the liberation of His, 5-HT, and BK
Santos et al., 2011 [29]	C. nemorosa	LHxE	Swiss mice	50–200 mg/kg	i.p.	CIP; MTP; MTNF-𝛼; GGICP	Inhibition of the neutrophil migration

Abbreviations of parts used: APME: aerial parts methanol extract; APEE: aerial parts ethanolic extract; APOOE: aerial parts olive oil extract; BEAE: bark ethyl acetate extract; BHE: bark hydroalcoholic extract; BME: blossom methanol extract; DAPE: dried aerial parts extract; FPE: fruit peel extract; FPO: fruit pee oil; FTOE: flowering tops oil extracts; LAE: leaves aqueous extract; LHE: leaves hydroalcoholic extract; LEE: leaves ethanolic extract; LHxE: leaves hexanic extract; ME: methanolic extract; SBAE: stem bark aqueous extract; SBMCME: stem barks methylene chloride/methanol extract; SHE: seeds hydroalcoholic extract.
Abbreviations of administration routes: i.p.: intraperitoneal; p.o.: oral administration; t.a.: topical administration.
Abbreviations of methods used: AAIPE: arachidonic acid-induced paw edema; AcAICP: acetic acid-induced increase in capillary permeability; BKIPE: bradykinin induced paw edema; CE: cytokines expression; CIP: carrageenan-induced pleurisy; CIPE: carrageenan-induced paw edema; CITNBS: colitis induced by 2,4,6-trinitrobenzenesulfonic acid; DIPE; dextran-induced paw edema; COIEE: croton oil-induced ear edema; EMPGE₂: evaluation of mucosal PGE₂; EPPIEE: ethyl phenylpropiolate induced ear edema; GGICP: granulomatous growth induced by cotton pellet; HSIPE: histamine and serotonin induced paw edema; MPOAA: myeloperoxidase activity assay; MTNF-𝛼: measurement of tumor necrosis factor alpha; MTP: measurement of total protein; PEILPS: peritonitis induced by lipopolysaccharide; PIL: peritonitis induced by ligature; PILPS: pleurisy induced by LPS; SPIPE: substance P induced paw edema; TPAIPE: 12-O-tetradecanoylphorbol 13-acetate induced paw edema.
Abbreviations of action mechanism: AA: arachidonic acid; BK: bradykinin; COX: cyclooxygenase; His: histamine; iNOS: inducible nitric oxide synthase; KN: kinins; LOX: lipoxygenase; MVP: measurement of vascular permeability; NF-𝜅B: nuclear factor kappa B; PKC: protein kinase C; PLA2: phospholipase A2; PG: prostaglandin, 5-HT: 5-hydroxytryptamine.