Naja naja atra Venom Protects against Manifestations of Systemic Lupus Erythematosus in MRL/lpr Mice
Figure 2
NNAV reduced the proteinuria. During the 16 weeks of NNAV administration, proteinuria (a) in each group was measured with Multistix 8 SG strips following the manufacturer’s instructions, where 0 10 mg/dL, 1 = 11–30 mg/dL, 2 = 30–100 mg/dL, 3 = 100–300 mg/dL, 4 = 300–2,000 mg/dL, and 5 2,000 mg/dL. Data represent mean values ± SD from 8 to 10 mice per group. (versus model). At the end of the study, kidneys from each mouse were collected and the kidney sections (b) were stained with hematoxylin and eosin and observed with a microscopy at 100x magnification. The index of lupus nephritis (c) was scored according to histopathologic appearance of kidney section. Data represent mean values ± SD from 4 mice per group. (versus model).
