Gene Expression Profiles Underlying Selective T-Cell-Mediated Immunity Activity of a Chinese Medicine Granule on Mice Infected with Influenza Virus H1N1

Table 2

Genes associated with Toll-like receptor signaling pathway.

Symbol	GenBank accession	Gene description	log2 FC^a
			M/N	SH/M	SM/M	SL/M	Oseltamivir/M
Tlr7	mMC009252	Toll-like receptor 7, TLR7	1.39	0.02	−2.02	−0.43	−0.92
MyD88	PH_mM_0009196	Myeloid differentiation primary response gene 88	2.22	−1.18	−2.63	−1.36	−1.62
Mapk8	PH_mM_0009123	Mitogen-activated protein kinase 8, JNK	1.82	−1.14	−1.22	−1.04	−1.24
Mapk13	PH_mM_0004240	Mitogen-activated protein kinase 13, P38	1.39	−2.27	−1.89	−2.10	−1.50
Tnf	mMC016605	Tumor necrosis factor, TNF-α	5.47	−3.86	−5.03	−4.58	−4.60
Il1b	mMC010962	Interleukin 1 beta, IL-1β	3.69	−2.92	−4.27	−2.33	−2.47
Cxcr2	PH_mMC_0000540	Chemokine (C-X-C motif) receptor 2, IL-8	1.93	−2.80	−3.25	−2.25	−2.22
Ccl5	mMC0118383	Chemokine (C-C motif) ligand 5, RANTES	3.51	−0.93	−3.39	−1.95	−2.26
Tgfb1	PH_mMC_0001301	Transforming growth factor, beta 1	1.46	−0.84	−1.25	−0.92	−1.35
Csf2	mMC014357	Colony stimulating factor 2	2.41	−1.40	−2.03	−1.43	−2.19
Il18	mMC021817	Interleukin 18, IL-18	2.02	−0.66	−1.10	−0.76	−1.26
Il12a	PH_mM_0009192	Interleukin 12a, IL-12	3.38	−3.32	−2.92	−2.91	−3.05

aFold change. The intensity ratio of probe signal criteria for differential expressions was defined as a twofold change (up or down) (log₂ FC ≥ 1 or ≤−1) in gene expression compared with virus control group and a 𝑃 value less than 0.05 in at least one time point as a minimum requirement to select. For instance, log₂ (M/N) ≥ 1 means that the comparison between normal control group and virus control group was scattered, indicating that a large number of genes in virus control group were up-regulated in response to H1N1 infection. log₂ (SH/M) ≤−1, log₂ (SM/M) ≤−1, log₂ (SL/M) ≤−1, and log₂ (Oseltamivir/M) ≤−1 means that down-regulation in gene expression attributable to the high-dose SFXF group treatment, medium-dose group SFXF treatment, low-dose SFXF group treatment, and Oseltamivir group treatment was done by comparing genes in virus control group, respectively (𝑃 value data not shown).