Research Article
Pharmacokinetics and Tissue Distribution Study of Chlorogenic Acid from Lonicerae Japonicae Flos Following Oral Administrations in Rats
Table 2
The stability of plasma samples.
| | Stability type | Time and | Added concentration (g/L) | Mean measured concentration (g/L) | Accuracy
(%) | RSD (%) |
| | Short-term stability | 3 h () | 15.63 | 14.30 | 91.5 | 7.0 | | 125.00 | 131.4 | 105.1 | 5.7 | | 800.00 | 825.5 | 103.2 | 3.0 | | 6 h () | 15.63 | 14.22 | 91.0 | 6.8 | | 125.00 | 133.6 | 106.9 | 6.2 | | 800.00 | 806.5 | 100.8 | 5.4 |
| | Postpreparative stability | 6 h () | 15.63 | 14.30 | 91.5 | 7.0 | | 125.00 | 131.4 | 105.1 | 5.7 | | 800.00 | 825.5 | 103.2 | 3.0 | | 12 h () | 15.63 | 15.252 | 97.6 | 9.5 | | 125.00 | 130.3 | 104.2 | 6.4 | | 800.00 | 842 | 105.3 | 7.1 |
| | Freeze-thaw stability | After 3 freeze-thaw cycles
() | 15.63 | 13.74 | 87.9 | 7.7 | | 125.00 | 127.3 | 101.9 | 6.4 | | 800.00 | 771.3 | 96.4 | 4.6 |
| | Long-term stability | After 30 days () | 15.63 | 13.66 | 87.4 | 5.2 | | 125.00 | 122.1 | 97.7 | 3.1 | | 800.00 | 804.9 | 100.6 | 4.0 |
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