The Resin from Protium heptaphyllum Prevents High-Fat Diet-Induced Obesity in Mice: Scientific Evidence and Potential Mechanisms

Figure 5

Histology of liver tissue of mice fed the experimental diets for 15 weeks. Histology of liver tissue of mice fed the experimental diets for 15 weeks. Representative microphotographs of mouse liver fed (a) a normal diet showing normal architecture and hepatocytes; (b) high-fat diet showing focal parenchymatous inflammatory infiltrate, isolated hepatocyte necrosis, and mild steatosis; (c) high-fat diet + RPH 20 mg/kg; and (d) high-fat diet + sibutramine that show well-formed nucleated hepatocytes, slight dilated sinusoids, minimal inflammatory lymphocyte infiltration, and absence of lipid droplets (H&E, ×100).

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