The Resin from Protium heptaphyllum Prevents High-Fat Diet-Induced Obesity in Mice: Scientific Evidence and Potential Mechanisms

Table 1

Effects of Protium heptaphyllum resin (PHR) and sibutramine (SIB) treatment on body weights, net food, energy and water intake, relative weights of abdominal fat, and liver in mice fed experimental diets for 15 weeks.

Group	ND	HFD	HFD + RPH 10 mg/kg	HFD + RPH 20 mg/kg	HFD + SIB 10 mg/kg
Initial body wt (g)	25.10 ± 0.79	25.20 ± 0.55	25.20 ± 0.71	25.20 ± 0.64	25.10 ± 0.67
Final body wt (g)	40.38 ± 0.94	55.13 ± 2.35^a	45.38 ± 1.29^b	48.63 ± 1.47^b	40.56 ± 1.35^b
Net food intake (g/week)	31.65 ± 1.32	38.24 ± 3.03^a	27.17 ± 1.17^b	33.34 ± 1.40^b	27.21 ± 1.16^b
Net energy intake (kJ/mouse/day)	76.97 ± 2.89	117.06 ± 9.20^a	83.03 ± 3.63^b	101.86 ± 4.28	83.25 ± 3.63^b
Net water intake (mL/week)	48.13 ± 0.73	47.63 ± 1.66	44.44 ± 1.20	41.91 ± 1.38	42.54 ± 0.72
Abdominal fat (mg/10 g of body wt)	195.4 ± 24.59	695.4 ± 96.60^a	421.5 ± 79.22^b	457.6 ± 28.38^b	359.1 ± 62.21^b
Liver wt (mg/10 g of body wt)	337.9 ± 13.60	413.1 ± 7.32^a	378.5 ± 16.69	341.5 ± 9.56^b	368.4 ± 11.54

Values are mean ± SEM (n = 8). ND: normal diet; HFD: high fat diet; RPH: resin of Protium heptaphyllum; SIB: sibutramine. ^aP < 0.05 versus mice fed ND; ^bP < 0.05 versus mice fed HFD (ANOVA followed by Student-Newman-Keuls test).