Review Article

Acupuncture Therapy Is More Effective Than Artificial Tears for Dry Eye Syndrome: Evidence Based on a Meta-Analysis

Table 1

Baseline characteristics of studies included in the meta-analysis.

Study IDInterventionsPatients, Male, (%)Age, yearsTreatment frequencyMain outcomesStudy type

Nepp et al., 1998 [23]Acupuncture
Artificial tears
30
22
NA
NA
NA
NA
Once per week
NA
BUT, SIT, and registration of drop frequencyRCT

Grönlund et al., 2004 [24]Acupuncture
Artificial tears
12
13
1 (10)
2 (20)
61 (38–79)
51 (37–75)
Once to twice per week
NA
BUT, SIT, VAS, registration of drop frequency, and questionnaire on symptomsRCT

He et al., 2004 [25]Acupuncture16NANAOnce in 2 days, 10 times/course, 3 courses, 10 days’ rest after a courseBUT, SIT, and CFSRCT
Artificial tears16NANA5 to 6 times one day, for 30 days

Wang et al., 2005 [26] Acupuncture 1157 (46.7)51.7 (27–75)Once in 2 days, 10 times/course, 3 courses, 10 days’ rest after a courseBUT, SIT, and CFSRCT
Acupuncture 2155 (33.3)51.8 (24–74)Once in 2 days, 10 times/course, 3 courses, 10 days’ rest after a course
Artificial tears155 (33.3)51.5 (30–73)5 times one day, for 30 days

Tseng et al., 2006 [27]Acupuncture
Artificial tears
17
9
6 (35.3)
6 (66.7)
47.58 ± 14.88
51.33 ± 20.91
Twice a week, 2 to 3 day apart, for 8 weeks
NA
BUT, SIT, VAS, Over score of eye conditionRCT

Shi and Miao, 2012 [5]Acupuncture
Artificial tears
33
35
14 (42.4)
16 (45.7)
47.4 ± 12.70
51.4 ± 10.50
Three times a week, for three weeks
Three to four times per day, for three weeks
BUT, SIT, lactoferrin concentrationRCT

Kim et al., 2012 [28]Acupuncture
Artificial tears
75
75
22 (41.5)
19 (33.9)
47.95 ± 11.11
46.05 ± 13.10
Three times per week, for four weeks
at least once per day, for four weeks
BUT, SIT, VAS, Quality of lifeRCT

BUT, tear break-up time; SIT, Schirmer test; CFS, cornea fluoresce in staining; VAS, visual analogue scale; NA, not available.