Bathing Effects of Various Seawaters on Allergic (Atopic) Dermatitis-Like Skin Lesions Induced by 2,4-Dinitrochlorobenzene in Hairless Mice

Figure 3

Changes of the serum IgE levels after 6 weeks of continuous bathing on seawaters or topical application of DEXA in DNCB-induced AD mice. Significant () increases of serum total IgE levels were detected in DNCB control mice as compared with intact vehicle control hairless mice. However, significant () decreases of serum total IgE levels were detected by topical treatment of 1% DEXA, bathing on the ESGW, WSGW, ESSW, and WSSW as compared with DNCB control mice, in that order, respectively. Values are expressed as mean ± SD of eight hairless mice. AD = allergic/atopic-like dermatitis; DNCB = 2,4-dinitrochlorobenzene; DEXA = dexamethasone-water soluble; WSSW = west surface seawater collected around Wepo-ri (Ganghwa-do, Republic of Korea); WSGW = west saline groundwater collected at Yonggungoncheon (Seokmo-do, Republic of Korea); ESSW = east surface seawater collected around Nagok-ri (Uljin, Republic of Korea); ESGW = east saline groundwater collected around Hoojeong-ri (Uljin, Republic of Korea); Ig = immunoglobulin. and as compared with intact control by LSD test; as compared with DNCB control by LSD test.