Bathing Effects of Various Seawaters on Allergic (Atopic) Dermatitis-Like Skin Lesions Induced by 2,4-Dinitrochlorobenzene in Hairless Mice

Table 3

Changes on the scratching behaviors during 6 weeks of continuous bathing on seawaters or topical application of DEXA in DNCB-induced AD mice.

Index	Controls		DEXA	Bathing on
	Intact	DNCB		WSSW	WSGW	ESSW	ESGW
Days after initial DNCB sensitization
35	15.31 ± 9.09	478.13 ± 112.61^a	480.88 ± 109.99^a	484.50 ± 105.49^a	480.63 ± 101.37^a	475.50 ± 97.90^a	481.88 ± 120.67^a
38	13.63 ± 6.07	468.50 ± 111.31^a	436.13 ± 101.11^a	461.13 ± 106.48^a	441.50 ± 87.29^a	455.25 ± 93.97^a	435.38 ± 88.52^a
42	13.00 ± 4.41	456.25 ± 102.61^a	324.88 ± 88.38^ac	448.13 ± 101.73^a	393.00 ± 52.97^a	415.00 ± 76.14^a	390.00 ± 77.26^a
49	14.63 ± 6.67	448.63 ± 97.87^a	223.25 ± 47.38^ab	407.00 ± 85.47^a	340.50 ± 42.52^ac	369.50 ± 68.29^a	432.00 ± 53.17^ac
56	16.63 ± 5.42	431.25 ± 90.00^a	177.50 ± 22.67^ab	381.38 ± 83.58^a	306.88 ± 27.97^ab	355.63 ± 66.34^a	299.38 ± 32.11^ab
63	17.38 ± 5.60	412.38 ± 68.67^a	149.25 ± 34.85^ab	312.13 ± 66.85^ac	290.38 ± 37.89^ab	307.88 ± 39.20^ab	273.63 ± 29.66^ab
70	18.00 ± 4.28	410.50 ± 77.21^a	90.63 ± 24.11^ab	288.38 ± 70.04^ab	251.75 ± 26.60^ab	284.00 ± 39.37^ab	229.75 ± 24.02^ab
77	19.25 ± 5.06	405.00 ± 65.20^a	70.88 ± 30.89^ab	273.00 ± 63.19^ab	230.25 ± 27.77^ab	258.88 ± 30.68^ab	203.75 ± 24.32^ab

Values are expressed as mean ± SD of eight hairless mice, frequencies/30 min. AD = allergic/atopic-like dermatitis; DNCB = 2,4-dinitrochlorobenzene; DEXA = dexamethasone-water soluble; WSSW = west surface seawater collected around Wepo-ri (Ganghwa-do, Republic of Korea); WSGW = west saline groundwater collected at Yonggungoncheon (Seokmo-do, Republic of Korea); ESSW = east surface seawater collected around Nagok-ri (Uljin, Republic of Korea); ESGW = east saline groundwater collected around Hoojeong-ri (Uljin, Republic of Korea). ^a as compared with intact control by MW test; ^b and ^c as compared with DNCB control by MW test.