Bathing Effects of Various Seawaters on Allergic (Atopic) Dermatitis-Like Skin Lesions Induced by 2,4-Dinitrochlorobenzene in Hairless Mice
Table 3
Changes on the scratching behaviors during 6 weeks of continuous bathing on seawaters or topical application of DEXA in DNCB-induced AD mice.
Index
Controls
DEXA
Bathing on
Intact
DNCB
WSSW
WSGW
ESSW
ESGW
Days after initial DNCB sensitization
35
15.31 ± 9.09
478.13 ± 112.61a
480.88 ± 109.99a
484.50 ± 105.49a
480.63 ± 101.37a
475.50 ± 97.90a
481.88 ± 120.67a
38
13.63 ± 6.07
468.50 ± 111.31a
436.13 ± 101.11a
461.13 ± 106.48a
441.50 ± 87.29a
455.25 ± 93.97a
435.38 ± 88.52a
42
13.00 ± 4.41
456.25 ± 102.61a
324.88 ± 88.38ac
448.13 ± 101.73a
393.00 ± 52.97a
415.00 ± 76.14a
390.00 ± 77.26a
49
14.63 ± 6.67
448.63 ± 97.87a
223.25 ± 47.38ab
407.00 ± 85.47a
340.50 ± 42.52ac
369.50 ± 68.29a
432.00 ± 53.17ac
56
16.63 ± 5.42
431.25 ± 90.00a
177.50 ± 22.67ab
381.38 ± 83.58a
306.88 ± 27.97ab
355.63 ± 66.34a
299.38 ± 32.11ab
63
17.38 ± 5.60
412.38 ± 68.67a
149.25 ± 34.85ab
312.13 ± 66.85ac
290.38 ± 37.89ab
307.88 ± 39.20ab
273.63 ± 29.66ab
70
18.00 ± 4.28
410.50 ± 77.21a
90.63 ± 24.11ab
288.38 ± 70.04ab
251.75 ± 26.60ab
284.00 ± 39.37ab
229.75 ± 24.02ab
77
19.25 ± 5.06
405.00 ± 65.20a
70.88 ± 30.89ab
273.00 ± 63.19ab
230.25 ± 27.77ab
258.88 ± 30.68ab
203.75 ± 24.32ab
Values are expressed as mean ± SD of eight hairless mice, frequencies/30 min. AD = allergic/atopic-like dermatitis; DNCB = 2,4-dinitrochlorobenzene; DEXA = dexamethasone-water soluble; WSSW = west surface seawater collected around Wepo-ri (Ganghwa-do, Republic of Korea); WSGW = west saline groundwater collected at Yonggungoncheon (Seokmo-do, Republic of Korea); ESSW = east surface seawater collected around Nagok-ri (Uljin, Republic of Korea); ESGW = east saline groundwater collected around Hoojeong-ri (Uljin, Republic of Korea). a as compared with intact control by MW test; b and c as compared with DNCB control by MW test.