Bathing Effects of Various Seawaters on Allergic (Atopic) Dermatitis-Like Skin Lesions Induced by 2,4-Dinitrochlorobenzene in Hairless Mice

Table 4

Changes on the lymphatic organ weights after 6 weeks of continuous bathing on seawaters or topical application of DEXA in DNCB-induced AD mice.

Groups	Absolute weights (g)		Relative weights (% of body weights)
	Spleen	Submandibular LN	Spleen	Submandibular LN
Controls
Intact	0.098 ± 0.014	0.007 ± 0.003	0.395 ± 0.069	0.029 ± 0.009
DNCB	0.237 ± 0.032^a	0.019 ± 0.003^a	0.909 ± 0.135^a	0.073 ± 0.011^a
Reference
DEXA	0.123 ± 0.017^bc	0.009 ± 0.002^c	0.472 ± 0.082^c	0.035 ± 0.00^bc
Bathing on
WSSW	0.192 ± 0.026^ac	0.015 ± 0.003^ac	0.730 ± 0.092^ac	0.057 ± 0.007^ac
WSGW	0.163 ± 0.027^ac	0.013 ± 0.003^ac	0.640 ± 0.094^ac	0.052 ± 0.013^ac
ESSW	0.177 ± 0.023^ac	0.014 ± 0.003^ac	0.705 ± 0.115^ac	0.055 ± 0.015^ac
ESGW	0.144 ± 0.021^ac	0.012 ± 0.002^ac	0.564 ± 0.076^ac	0.046 ± 0.009^ac

Values are expressed as mean ± SD of eight hairless mice, frequencies/30 min. AD = allergic/atopic-like dermatitis; DNCB = 2,4-dinitrochlorobenzene; DEXA = dexamethasone-water soluble; WSSW = west surface seawater collected around Wepo-ri (Ganghwa-do, Republic of Korea); WSGW = west saline groundwater collected at Yonggungoncheon (Seokmo-do, Republic of Korea); ESSW = east surface seawater collected around Nagok-ri (Uljin, Republic of Korea); ESGW = east saline groundwater collected around Hoojeong-ri (Uljin, Republic of Korea). ^a and ^b as compared with intact control by LSD test; ^c as compared with DNCB control by LSD test.