Bathing Effects of Various Seawaters on Allergic (Atopic) Dermatitis-Like Skin Lesions Induced by 2,4-Dinitrochlorobenzene in Hairless Mice

Table 8

General skin tissues histomorphometry after 6 weeks of continuous bathing on seawaters or topical application of DEXA in DNCB-induced AD mice.

Index	Controls		DEXA	Bathing on
	Intact	DNCB		WSSW	WSGW	ESSW	ESGW
Epithelial Th	29.72 ± 6.61	113.81 ± 21.68^d	36.60 ± 5.03^ef	70.08 ± 15.31^df	53.28 ± 10.49^df	59.34 ± 11.17^df	46.95 ± 7.80^df
Collagen fOP	41.20 ± 6.97	79.36 ± 7.91^a	78.48 ± 7.72^a	65.35 ± 9.43^ac	58.92 ± 8.01^ac	62.00 ± 8.66^ac	51.79 ± 7.77^bc
Infiltrated cells
IF	22.00 ± 11.54	390.25 ± 115.56^d	70.13 ± 21.72^df	233.38 ± 60.46^df	161.63 ± 26.80^df	215.75 ± 18.91^df	126.25 ± 29.03^df
Mast	124.88 ± 42.04	819.25 ± 102.87^a	221.50 ± 37.03^bc	628.25 ± 101.19^ac	492.88 ± 112.89^ac	572.50 ± 92.16^ac	341.00 ± 71.43^ac

Values are expressed as mean ± SD of eight hairless mice. AD = allergic/atopic-like dermatitis; DNCB = 2,4-dinitrochlorobenzene; DEXA = dexamethasone-water soluble; WSSW = west surface seawater collected around Wepo-ri (Ganghwa-do, Republic of Korea); WSGW = west saline groundwater collected at Yonggungoncheon (Seokmo-do, Republic of Korea); ESSW = east surface seawater collected around Nagok-ri (Uljin, Republic of Korea); ESGW = east saline groundwater collected around Hoojeong-ri (Uljin, Republic of Korea); Th = thickness; fOP = fiber occupied region percentages; IF = inflammatory. ^a and ^b as compared with intact control by LSD test; ^c as compared with DNCB control by LSD test; ^d and ^e as compared with intact control by MW test; ^f as compared with DNCB control by MW test.