Evidence-Based Complementary and Alternative Medicine / 2015 / Article / Tab 2 / Research Article
The Activation of Nrf2 and Its Downstream Regulated Genes Mediates the Antioxidative Activities of Xueshuan Xinmaining Tablet in Human Umbilical Vein Endothelial Cells Table 2 Differentially regulated oxidative stress-related genes in HUVECs following XXT treatment.
Gene Description GenBank accession number Fold Change GCLM Glutamate-cysteine ligase modifier subunit NM_002061 6.25 0.0488 NQO1
NAD(P)H dehydrogenase, quinone 1 NM_000903 4.55 0.0004 TXN Thioredoxin NM_003329 3.70 0.0376 FTH1 Ferritin, heavy polypeptide 1 NM_002032 3.03 0.0081 GPX6 Glutathione peroxidase 6 (olfactory) NM_182701 2.56 0.0449 HMOX1 Heme oxygenase (decycling) 1 NM_002133 2.50 0.0323 OXSR1 Oxidative stress responsive 1 NM_005109 2.17 0.0024 SELS Selenoprotein S NM_203472 2.13 0.0297 PTGS1 Prostaglandin-endoperoxide synthase 1 NM_000962 0.12 0.0227 DHCR24 24-Dehydrocholesterol reductase NM_014762 0.21 0.0074 MB Myoglobin NM_005368 0.22 0.0390 CAT Catalase NM_001752 0.24 0.0021 UCP2 Uncoupling protein 2 NM_003355 0.25 0.0013 GTF2I General transcription factor IIi NM_001518 0.27 0.0013 PDLIM1 PDZ and LIM domain 1 NM_020992 0.30 0.0042 PRDX2 Peroxiredoxin 2 NM_005809 0.31 0.0422 GSTZ1 Glutathione transferase zeta 1 NM_001513 0.32 0.0014
