Review Article
Jasada bhasma, a Zinc-Based Ayurvedic Preparation: Contemporary Evidence of Antidiabetic Activity Inspires Development of a Nanomedicine
Table 2
A summary of metabolic actions of zinc and their mechanism.
| Metabolic action | Mechanism of action | References |
| Increases insulin action | Increases stability and receptor binding | [11, 12] | Improves insulin signaling | PTP1B inhibition | [16] | Enhances insulin signaling | Increases receptor phosphorylation and PI3K activity | [17] | Beneficial effect on glycogen metabolism | GSK3 inhibition | [14] | Increases glucose uptake | GLUT4 translocation in adipocytes | [19, 20] | Decreases lipolysis | Inhibition of HSL and FFA release | [21] | Inhibits glucagon secretion | Opening of KATP channels in pancreatic alpha cells | [22, 23] | Inhibits intestinal glucose absorption | Inhibits alpha-glucosidase enzyme | [18] | Reduces oxidative stress | Enhances SOD activity | [25] | Protects beta cells | Modulates NFκB activation | [26] |
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