[Retracted] Topical Treatment with Xiaozheng Zhitong Paste (XZP) Alleviates Bone Destruction and Bone Cancer Pain in a Rat Model of Prostate Cancer-Induced Bone Pain by Modulating the RANKL/RANK/OPG Signaling

Figure 2

XZP treatment reduces the cancer-induced bone damage in rats. At 21 days after inoculation, the tibial bone structure and damage in the individual rats were characterized by X-rad and micro-CT and quantitatively analyzed. Subsequently, their tibial bone sections were stained with HE. Data are representative images of individual groups of rats ( per group). (a) Radiographs of the bone structure and tumor invasion. (b) 3D micro-CT images of the tibias. (c) HE analysis of the cancer bone tissues (magnification ×400). Low dose, medium dose, and high dose. The rats were treated with low, medium, or high dose of XZP. ( versus the control group; versus the placebo group; versus placebo group).

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