1,2,3,4,6-Penta-O-galloylglucose within Galla Chinensis Inhibits Human LDH-A and Attenuates Cell Proliferation in MDA-MB-231 Breast Cancer Cells

Figure 5

(a) hLDH-A (0.02 units/mL) enzyme inhibition by PGG. The data represent hLDH-A activity as % control (NADH oxidation) at 60 minutes and are expressed as the mean ± SEM, with significance from controls determined with a one-way ANOVA followed by Bonferroni’s multiple comparison test; , . IC₅₀ = 27.17 nM. (b) hLDH-A enzyme inhibition by reference known inhibitor (oxalic acid). The data represent hLDH-A activity as % control (NADH oxidation) at 60 minutes and are expressed as the mean ± SEM, with significance from controls determined using a one-way ANOVA followed by Bonferroni’s multiple comparison test; , , IC₅₀ > 6 mM.

(a)

(b)