The Chondroprotective Role of TMF in PGE₂-Induced Apoptosis Associating with Endoplasmic Reticulum Stress

Figure 4

Changes in protein expression of GSK-3β, PERK, p-PERK, eIF2α, p-eIF2α, ATF6, IRE1α, XBP1, CHOP, BAX, and BAK. Chondrocytes in the control, the model groups, and the treated groups were incubated with 1 μM PGE₂ and 5, 10, and 20 μg/mL TMF for 48 h, respectively. The changes of proteins expression were detected by Western blot. GAPDH was used as internal control. Data were presented by mean ± SD of 4 replicates. as compared with the model.