A Special Extract of Bacopa monnieri (CDRI-08)-Restored Memory in CoCl₂-Hypoxia Mimetic Mice Is Associated with Upregulation of Fmr-1 Gene Expression in Hippocampus

Figure 2

Effects of CDRI-08 on spatial memory of hypoxic mice. (a) Pattern of latency; (b) path length; (c) number of platform crossing, and (d) time spent in target quadrant. Values are expressed as mean ± S.E.M. versus control; versus control; versus HA; ^# versus HB. (e) Track record for probe trail of mice following exposure to hypoxia mimetic condition and CDRI-08 treatment. Q1: Quadrant 1; Q2: Quadrant 2; Q3: Quadrant 3; Q4: Quadrant 4 (target quadrant). Mice administered with BME: Brahmi; HA, treatment of CoCl₂ for 15 days to induce hypoxia; HB: hypoxic mice left for 8 days without any treatment after CoCl₂ treatment for 15 days; B + H: mice pretreated with CDRI-08 followed by CoCl₂ treatment; H + B: CDRI-08 treated hypoxic mice.

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