Farnesol, a Sesquiterpene Alcohol in Herbal Plants, Exerts Anti-Inflammatory and Antiallergic Effects on Ovalbumin-Sensitized and -Challenged Asthmatic Mice

Figure 2

Farnesol supplementation effects with different doses for 5 weeks on IL-4 (a), IL-5 (b), IL-10 (c), IL-2 (d), IFN-γ (e), and (IL-4 + IL-5 + IL-10)/(IL-2 + IFN-γ) ratios (f) secreted by splenocytes of OVA/AL-sensitized and -challenged BALB/c asthmatic mice. Values are means ± SD (). Values among groups within the same treatment not sharing a common small letter are significantly different () from each other and assayed by one-way ANOVA, followed by Duncan’s new multiple range test. The limit of detection (LOD) of these kits used in this study was <3.9 pg/mL. NSC, nonsensitized control; DC, dietary control; PC, positive control (dexamethasone, 3 mg/kg BW, 0.3 mL/mouse by gavage); FL, low dose farnesol (0.003% in AIN-76 feed); FM, medium dose farnesol (0.017% in AIN-76 feed); FH, high dose farnesol (0.067% in AIN-76 feed).

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