Potent Antiproliferative Effect on Liver Cancer of Medicinal Plants Selected from the Thai/Lanna Medicinal Plant Recipe Database “MANOSROI III”

Table 1

Botanical names, families, part used, yields, and antiproliferative activity on human hepatoma cell line (HepG2) of the 23 methanol extracts of the medicinal plant selected from Thai/Lanna medicinal recipe database “MANOSROI III.”

Plant number

Name of the medicinal plant

Family

Part used

Yield (w/w%)

Voucher specimen number

Local name

English name

Antiproliferative activity on Hep G2

IC50 (µg/mL)

Folds of

NCI criteria

Rank

C

D

1

Acanthus ebracteatus Vahl

Acanthaceae

Stem

11.50

MANOSROI#0033

Ngueak Pla Moh

Sea holly

>1000

ND

ND

IA

15

2

Aegle marmelos (L.) Correa ex Roxb.

Rutaceae

Fruit

43.88

MANOSROI#0034

Ma Toom

Bael

>1000

ND

ND

IA

15

3

Albizia chinensis (Osbeck) Merr.

Leguminosae-Mimosoideae

Wood

5.79

MANOSROI#0021

Kang Luang

Silk tree

34.50

0.77

0.02

MA

7

4

Caesalpinia sappan L.

Caesalpiniaceae

Wood

14.23

MANOSROI#0022

Nam Khong, Fang

Sappan tree

20.12

1.31

0.03

MA

3

5

Cassia fistula L.

Leguminosae

Wood

6.71

MANOSROI#0012

Ratcha Phruek

Golden shower

372.23

0.07

0.00

IA

11

6

Fibraurea tinctoria Lour.

Menispermaceae

Wood

7.04

MANOSROI#0035

Kamphaeng Ched Chan

—

89.11

0.30

0.01

MA

9

7

Gloriosa superba L.

Colchicaceae

Root

7.92

MANOSROI#0036

Dong Dueng

Flame lily

20.11

1.31

0.03

MA

2

8

Hydnophytum formicarum Jack

Rubiaceae

Bulb

17.06

MANOSROI#0037

Hua Roi Ru

Ant plant

129.02

0.20

0.00

IA

10

9

Nymphoides indica Ktze.

Gentianaceae

Wood

8.37

MANOSROI#0025

Tab Tao Yai

Water snowflake

>1000

ND

ND

IA

15

10

Peltophorum pterocarpum (DC.) Backer ex K. Heyne

Leguminosae-Caesalpinoideae

Wood

10.52

MANOSROI#0023

San Ngoen

Copper pod

395.01

0.07

0.00

IA

13

11

Polyalthia debilis Pierre Finet et Gagnep.

Annonaceae

Wood

5.96

MANOSROI#0024

Kluay Tao, Tab Tao

—

>1000

ND

ND

IA

15

12

Pouzolzia pentandra Benn.

Urticaceae

Leaf

5.54

MANOSROI#0045

Kob Cha Nang Dang

—

35.51

0.74

0.02

MA

8

13

Psocarpus tetragonolobus (L.) DC.

Leguminosae-Papilionoideae

Rhizome

10.07

MANOSROI#0003

Thua Phu

Winged bean

>1000

ND

ND

IA

15

14

Rhinacanthus nasutus (L.) Kurz

Acanthaceae

Whole

8.61

MANOSROI#0038

Thong Phan Chang

Snake jasmine

30.91

0.85

0.02

MA

6

15

Senna alata (L.) Roxb.

Leguminosae-Caesalpinoideae

Root

21.52

MANOSROI#0030

Chumhet Thet

Candle tree

22.46

1.18

0.02

MA

5

16

Sida rhombifolia L.

Malvaceae

Root

7.68

MANOSROI#0020

Ya Khat, Khat Mon

Paddy’s lucerne

>1000

ND

ND

IA

15

17

Smilax glabra Wall ex Roxb.

Smilaceae

Bulb

17.05

MANOSROI#0039

Khao Yen Tai

China root

>1000

ND

ND

IA

15

18

Smilax corbularia Kunth

Smilaceae

Bulb

17.22

MANOSROI#0040

Khao Yen Nuea

Long-leaved greenbrier

>1000

ND

ND

IA

15

19

Stemona collinsae Craib

Stemonaceae

Stem

23.00

MANOSROI#0041

Non Tai Yak

—

5.51

4.79

0.10

A

1

20

Suregada multiflora (A. Juss.) Baill

Euphorbiaceae

Wood

6.35

MANOSROI#0042

Khan Thong Phayabat

Flase lime

>1000

ND

ND

IA

15

21

Tiliacora triandra Diels.

Menispermaceae

Leaf

12.90

MANOSROI#0043

Thao Ya Nang

—

487.85

0.05

0.00

IA

14

22

Urceola minutiflora Pierre. (DJ. Middleton)

Apocynaceae

Vine

9.64

MANOSROI#0026

Thao Muak Khao

—

>1000

ND

ND

IA

15

23

Ventilago denticulata Wild.

Rhamnaceae

Stem

4.97

MANOSROI#0044

Thaowal Lek

—

20.88

1.26

0.03

MA

4

Standard

Cisplatin (C)

26.41

1

—

—

—

Doxorubicin (D)

0.54

—

1

—

—

NCI criteria: the criteria indicated 3 types of activity. A: active (IC₅₀ < 20 mg/mL), MA: moderately active (IC₅₀ = 20~100 mg/mL), and IA: inactive (IC₅₀ > 100 mg/mL). ND: not determined. 1 of 23 plants (4.34%) was found active (A) and 8 of 23 plants (34.78%) were found moderately active (MA).