Potent Antiproliferative Effect on Liver Cancer of Medicinal Plants Selected from the Thai/Lanna Medicinal Plant Recipe Database “MANOSROI III”
Table 3
Antiproliferative activity on HepG2 cell line, DPPH radical scavenging and metal chelating activities and total phenolic and flavonoid contents of 7 semipurified fractions from the HF of V. denticulata ME.
Number
Extracts of Ventilago denticulata
Hep G2
DPPH
Chelating
Phenolic content
Flavonoid content
IC50 (µg/mL)
Folds of
NCI criteria
Rank
SC50 (µg/mL)
Folds of
Rank
CC50 (µg/mL)
Folds of
Rank
QE (µg/mg)
Rank
QE (µg/mg)
Rank
C
D
T
A
E
1
ME
20.88
1.26
0.03
MA
3
>100
ND
ND
—
>500
ND
5
83.73
3
10.08
6
2
HF
19.30
1.37
0.03
A
2
>100
ND
ND
—
>500
ND
5
48.75
4
26.00
5
3
HF-1
>100
—
—
IA
5
>100
ND
ND
—
319.60
0.04
3
12.70
7
36.63
2
4
HF-2
6.49
4.07
0.08
A
1
>100
ND
ND
—
>500
ND
5
7.41
8
35.08
3
5
HF-3
>100
—
—
IA
5
>100
ND
ND
—
>500
ND
5
32.75
6
33.52
4
6
HF-4
59.60
0.44
0.01
MA
4
>100
ND
ND
—
158.45
0.08
1
169.99
1
556.54
1
7
HF-5
>100
—
—
IA
5
>100
ND
ND
—
216.40
0.06
2
108.97
2
ND
8
8
HF-6
>100
—
—
IA
5
>100
ND
ND
—
375.33
0.03
4
27.40
5
5.90
7
9
HF-7
>100
—
—
IA
5
>100
ND
ND
—
>500
ND
5
6.54
9
ND
8
Standard
Cisplatin (C)
26.40
1.00
—
—
—
—
—
—
—
—
—
—
Doxorubicin (D)
0.54
—
1.00
—
—
—
—
—
—
—
—
—
α-Tocopherol (T)
—
—
—
—
—
23.80
1.00
0.77
—
NT
ND
—
Ascorbic acid (A)
—
—
—
—
—
18.30
1.30
1.00
—
NT
ND
—
EDTA (E)
—
—
—
—
—
NT
ND
ND
—
12.90
1.00
—
Folds of the standard drug were calculated as the ratio between the IC50 value of the standard drug and samples. NCI criteria: NCI criteria indicated three types of the activity. A: active (IC50 value was less than 20 µg/mL), MA: moderately active (IC50 value was between 20 and 100 µg/mL), and IA: inactive (IC50 value was more than 100 µg/mL). NT: not tested, ND: not determined. QE: quercetin equivalent.