Evaluation of Antinociceptive Activity of Ethanol Extract of Leaves of Adenanthera pavonina

Table 3

Effect of EEAP on involvement of cyclic guanosine monophosphate (cGMP) pathway.

Treatment (mg/Kg)	Writhing number (Mean ± SEM)	% Inhibition
Control (0.1 mL/mouse)	73.30 ± 2.76
MB (20)	55.70 ± 4.94	24.01
EEAP (50)	49.20 ± 3.58	32.88
EEAP (100)	39.60 ± 4.21	45.98
EEAP (200)	23.60 ± 1.47	67.80
MB (20) + EEAP (50)	41.30 ± 2.31	43.66
MB (20) + EEAP (100)	28.90 ± 2.87	60.57
MB (20) + EEAP (200)	10.20 ± 0.82^a	86.08

Values are presented as the mean ± SEM (). EEAP = ethanol extract of A. pavonina; MB = methylene blue; compared with the control group (Dunnett’s test); compared with the EEAP 200 mg/kg group (Bonferroni’s test).