Renoprotective Effects of Vitex megapotamica (Spreng.) Moldenke in C57BL/6 LDLr-Null Mice Undergoing High Fat Diet

Figure 5

Prolonged MEVM administration induces lipid-lowering and atheroprotective effects ((a)–(d)) in C57BL6 LDLr-null mice. Groups of mice () were treated for 5 weeks with commercial atherogenic diet. At the end of the second week the animals received varying doses of MEVM (30–300 mg/kg) or simvastatin (40 mg/kg) for three more weeks. All analyses were performed at the end of the experimental period (5 weeks). Values are expressed as mean ± SEM ( in each group) in comparison to the positive control (a; ) or negative control (b; ) using one-way ANOVA followed by Bonferroni test.

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