Renoprotective Effects of Vitex megapotamica (Spreng.) Moldenke in C57BL/6 LDLr-Null Mice Undergoing High Fat Diet
Table 2
Effects of the administration of the methanolic extract of Vitex megapotamica (MEVM) and simvastatin (SIMV) on urinary conductivity from LDLr-null mice.
Group
Conductivity (mS/cm)
Outset
Week 1
Week 2
Week 3
Week 4
Week 5
N. control
15.56 ± 0.11
15.36 ± 0.12
15.16 ± 0.22
14.26 ± 0.19
14.99 ± 0.21
15.01 ± 0.22
P. control
15.75 ± 0.11
14.99 ± 0.20
14.88 ± 0.18
15.01 ± 0.15
15.17 ± 0.19
12.29 ± 0.18b
MEVM (30)
15.46 ± 0.28
15.36 ± 0.19
15.94 ± 0.20
16.14 ± 0.21
15.21 ± 0.25
13.33± 0.19b
MEVM (100)
16.06 ± 0.23
16.10 ± 0.13
15.57 ± 0.18
15.27 ± 0.15
15.27 ± 0.15
15.57 ± 0.17
MEVM (300)
15.30 ± 0.22
15.20 ± 0.20
15.70 ± 0.19
17.96 ± 0.15a,b
17.16 ± 0.17a,b
17.99 ± 0.18a,b
SIMV (40)
16.29 ± 0.64
15.96 ± 0.20
14.99 ± 0.18
14.99 ± 0.18
15.01 ± 0.19
15.81 ± 0.19
Values are expressed as mean ± SEM ( in each group) in comparison to the positive control (a < 0.05) or negative control (b < 0.05) using one-way ANOVA followed by Bonferroni test.
