Evidence-Based Complementary and Alternative Medicine

Research Article

Ozone Therapy in the Management of Persistent Radiation-Induced Rectal Bleeding in Prostate Cancer Patients

Table 2

Rectal hemorrhage grading according to CTCAE.


Grade	Criteria	Before O₃T	End O₃T	Last follow-up

0	No symptoms	0	5	7
1	Mild; intervention not indicated	0	7	5
2	Moderate symptoms; medical intervention or minor cauterization indicated	2	0	0
3	Transfusion, radiologic, endoscopic, or elective operative intervention indicated	7	0	0
4	Life-threatening consequences; urgent intervention indicated	3	0	0

Note: CTCAE toxicity grade was significantly decreased at the end of O₃T () and at the last follow-up () compared to that before O₃T. Overall, the change in CTCAE toxicity grade was statistically significant ().
According to the National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE) grading system (version 4.0): available from http://evs.nci.nih.gov/ftp1/CTCAE/CTCAE_4.03_2010-06-14_QuickReference_5x7.pdf.