Evaluation of the Effects of Some Brazilian Medicinal Plants on the Production of TNF-α and CCL2 by THP-1 Cells
Table 3
IC50 values determined for selected extracts on in vitro inhibition of inflammatory mediators and radical scavenging activity.
Plant species
TNF-α (µg/mL ± SD)
CCL2 (µg/mL ± SD)
DPPH assay (µg/mL ± SD)
Inhibition ratio extract/rutin
Barbacenia flava
>250
>250
6.61 ± 1.7f
0.77
Calophyllum brasiliense
>250
>250
6.03 ± 2.2g
0.70
Caryocar brasiliense barks
>500
>250
6.13 ± 1.5g
0.71
Caryocar brasiliense leaves
224.0 ± 1.0
>250
3.01 ± 1.0k
0.35
Casearia sylvestris
124.0 ± 1.0
>250
5.70 ± 2.1gh
0.66
Coccoloba cereifera
194.3 ± 1.1
>250
4.12 ± 1.4i
0.48
Cuphea carthagenensis
>250
>250
5.40 ± 1.6h
0.62
Chrysophyllum marginatum
>500
>250
6.93 ± 1.3f
0.80
Erythroxylum gonocladum
>250
>250
8.81 ± 1.0cd
1.02
Erythroxylum suberosum
>250
>250
5.72 ± 2.0gh
0.66
Erythroxylum tortuosum
>250
>250
6.55 ± 1.0f
0.76
Lippia sidoides
>500
64.3 ± 1.0
7.56 ± 1.8e
0.88
Paepalanthus bromelioides
>250
>250
3.62 ± 1.4j
0.42
Phoenix roebelenii
>250
>250
6.56 ± 2.0f
0.76
Sida carpinifolia
>250
>250
13.23 ± 3.9a
1.54
Sida glaziovii
>250
>250
5.46 ± 2.4h
0.63
Terminalia catappa
>250
>250
6.12 ± 1.9g
0.71
Terminalia glabrescens
153.5 ± 1.1
189.4 ± 1.0
10.66 ± 1.9b
1.24
Vellozia piresiana
>250
>250
7.50 ± 4.2e
0.84
Rutin
ND
ND
8.58 ± 1.0d
1
ND: not determined. IC50 values were analyzed by one-way ANOVA, followed by Tukey’s test. Values with different letters differ statistically from each other according to Tukey’s test ().