Interaction of Glucagon G-Protein Coupled Receptor with Known Natural Antidiabetic Compounds: Multiscoring In Silico Approach

Table 1

Residues involved in binding all the finally selected compounds against GCGR.

Compounds	Gold fitness score	x-score (Kcal/mol)	Residues involved
			Hydrogen bonding	Hydrophobic interaction
Curcumin	48.53	−8.35	Y149, I235	Y145, K187, V191, I194, D195, M231, I235, E362, F365, L386
Amorfrutin 1	42.18	−8.37	K187	M231, Q232, I235, Y239, L307, V311, E362, V363, F365
4-hydroxyderricin	39.06	−8.56	No H-bond	Y145, K187, V191, I194, M231, I235, E362, F365, L386