Vitis vinifera (Muscat Variety) Seed Ethanolic Extract Preserves Activity Levels of Enzymes and Histology of the Liver in Adult Male Rats with Diabetes

Figure 1

Effect of the seed ethanolic extract of V. vinifera on liver histology. Representative images of the liver in (a) normal, (b) STZ-induced diabetic rats, (c) diabetic rats treated with 250 mg/kg/day V. vinifera seed extract, (d) diabetic rats treated with 500 mg/kg/day V. vinifera seed extract, and (e) diabetic rats treated with 600 μg/kg/day glibenclamide. Images were taken under 20× magnification. Scale bar represents 50 μm. In diabetic rats, several areas of moderate to severe necrosis could be seen around the central vein. Mild to absence of necrotic changes could be seen following treatment with 500 mg/kg/day V. vinifera or glibenclamide to diabetic rats. H = hepatocytes, CV = central vein, S = sinusoid, and N = necrosis (40× magnification).

(a)

(b)

(c)

(d)

(e)