Vitis vinifera (Muscat Variety) Seed Ethanolic Extract Preserves Activity Levels of Enzymes and Histology of the Liver in Adult Male Rats with Diabetes

Table 1

Effect of V. vinifera seed ethanolic extract on liver SDH, ICDH, MDH, LDH, and G-6-PPDH in streptozotocin-induced diabetic rats.

Parameters	Normal	Diabetic	Diabetic
			250 mg/kg; V. vinifera	500 mg/kg; V. vinifera	600 μg/kg; glibenclamide
SDH^#	4.51 ± 0.08	2.15^* ± 0.05	2.93^† ± 0.06	3.29^† ± 0.08	2.84^† ± 0.07
ICDH^#	0.78 ± 0.04	0.4^* ± 0.04	0.57^† ± 0.06	0.65^† ± 0.07	0.68^† ± 0.06
MDH^#	0.62 ± 0.08	0.32^* ± 0.08	0.48^† ± 0.06	0.53^† ± 0.08	0.56^† ± 0.09
LDH^#	0.94 ± 0.06	1.75^* ± 0.08	1.26^† ± 0.08	1.06^† ± 0.07	1.18^† ± 0.06
G-6-PDH^#	1.78 ± 0.04	0.73^* ± 0.06	1.27^† ± 0.08	1.44^† ± 0.05	1.38^† ± 0.06

(μ moles of formazan formed/mg protein/h). Value represents mean ± SD for 6 rats per group. ^*P < 0.05 as compared to normal, nondiabetic rats group and ^†P < 0.05 as compared to nontreated diabetic rats.