Research Article
In Vitro and In Vivo Anticancer Activity of Root Extracts of Sansevieria liberica Gerome and Labroy (Agavaceae)
Table 1
Effects of SL extracts against Sarcoma-180 ascites in BALB/c mice.
| Treatments | Dose (mg/kg) | Body weight (g) Day 1 | Body weight (g) Day 5 | Body weight (g) Day 9 | Body weight (g) Day 12 | Weight of tumor (g) | Volume of ascitic fluid (mL) | Number of tumor cells (×107) | Tumor growth inhibition (%) | Mortality (%) |
| Normal saline | (0.2 mL/mouse) | 21.09 ± 0.56 | 22.91 ± 0.71 | 25.18 ± 0.97 | 24.63 ± 1.49 | 7.28 ± 0.79 | 7.47 ± 0.80 | 178.07 ± 24.98 | 0 | 0 | 5-FU | 20 | 20.00 ± 0.53 | 20.57 ± 0.69a | 19.43 ± 1.27b | 19.83 ± 1.45a | 0.58 ± 0.37c | 0.53 ± 0.34c | 5.00 ± 3.42c | 97.19 | 0 | SL-A001 | 100 | 19.57 ± 0.57a | 21.43 ± 0.72 | | | | | | 0 | 0 | SL-A002 | 80 | 19.57 ± 0.57a | | 18.17 ± 0.70c | 17.80 ± 0.97b | | | | 62.34 | 0 | SL-A003 | 100 | 19.86 ± 0.55 | | | | 2.13 ± 0.75c | 2.13 ± 0.75c | | 65.15 | 42.86 | SL-A004 | 100 | 20.00 ± 0.53 | 20.71 ± 0.57a | | | | | | 23.54 | 14.29 |
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Values are mean ± SEM (, 11 for control). , , and versus normal saline; , , and versus 5-FU.
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