Effects of Green Tea Extracts on the Pharmacokinetics of Quetiapine in Rats

Table 1

Pharmacokinetic parameters of QUE in rats after administration of a single oral dose of 25.0 mg/kg with and without GTE (175 mg/kg) (mean ± SE, ).

Parameters	QUE alone (mean ± SE)	QUE with GTE (mean ± SE)
(ng/mL)	85.40 ± 34.22	47.49 ± 15.85^*
(h)	0.5	0.5
(ng⋅h/mL)	121.13 ± 32.59	78.16 ± 19.96^*
(ng⋅h/mL)	137.10 ± 29.16	84.22 ± 18.91^*
(h^−1)	0.24 ± 0.11	0.34 ± 0.19
(h)	3.49 ± 1.69	2.91 ± 2.22
CL (L/h/kg)	0.22 ± 0.04	0.34 ± 0.08
MRT (h)	3.50 ± 1.26	3.21 ± 1.69

Significant difference from “QUE alone” group with -test, ^* ≤ 0.05; : maximum plasma concentration; : time to maximum plasma concentration; AUC: area under curve; : elimination rate constant; : elimination half-life; CL: clearance; MRT: mean residence time.