Effects on Liver Lipid Metabolism of the Naturally Occurring Dietary Flavone Luteolin-7-glucoside

Figure 1

Schematic representation of the sterol receptor element-binding protein- (SREBP-) 1c and 2 transcription factors and respective target genes involved in fatty acid or cholesterol synthesis and uptake, respectively. SREBP-1c is activated in response to insulin and binds to sterol response elements (SRE) inducing target genes such as fatty acid synthase (FAS), while SREBP-2 activation induces 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGCR) and the low density lipoprotein receptor (LDLr) genes.