Curcumin Pharmacokinetic and Pharmacodynamic Evidences in Streptozotocin-Diabetic Rats Support the Antidiabetic Activity to Be via Metabolite(s)

Figure 5

AKT activation (a) and plasma membrane GLUT4 content (b) in gastrocnemius muscles of normal and STZ-diabetic rats treated with curcumin incorporated in yoghurt for 15 days. AKT activation was evaluated as phosphorylation levels in Ser-473 residues. Results are expressed as means ± SEM of the arbitrary units, -6 per group. Differences between groups were analyzed with one-way ANOVA followed by Student-Newman-Keuls test. # (): differences with NYOG and NC90; () and (): differences with DYOG; Φ (): differences between DC90 and NC90.

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